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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis, anti-inflammatory activity and molecular docking studies of 2,5-diarylfuran amino acid derivatives

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Author(s):
Stefani, Hello A. [1] ; Botteselle, Giancarlo V. [1] ; Zukerman-Schpector, Julio [2] ; Caracelli, Ignez [3] ; Correa, Denis da Silva [4] ; Farsky, Sandra H. P. [1] ; Machado, Isabel D. [1] ; Santin, Jose R. [1] ; Hebeda, Cristina B. [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Sao Paulo - Brazil
[2] Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Fis, BR-13560 Sao Carlos, SP - Brazil
[4] Univ Fed Sao Carlos, Programa Posgrad Biotecnol, BR-13560 Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; v. 47, p. 52-58, JAN 2012.
Web of Science Citations: 10
Abstract

A series of 2,5-diaryl substituted furans functionalized with several amino acids were synthesized and evaluated as the cyclooxygenases COX-1 and COX-2 enzymes inhibitors. The proline-substituted compound inhibited PGE(2) secretion by LPS-stimulated neutrophils, suggesting selectivity for COX-2. Molecular docking studies in the binding site of COX-2 were performed. (C) 2011 Elsevier Masson SAS. All rights reserved. (AU)