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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Functionalization of 2-(S)-isopropyl-5-iodo-pyrimidin-4-ones through Cu(I)-mediated 1,3-dipolar azide-alkyne cycloadditions

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Author(s):
Stefani, Helio A. [1] ; Amaral, Monica F. Z. J. [1] ; Manarin, Flavia [1] ; Ando, Romulo A. [2] ; Silva, Nathalia C. S. [1] ; Juaristi, Eusebio [3]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Quim, Sao Paulo - Brazil
[3] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Quim, Mexico City 07000, DF - Mexico
Total Affiliations: 3
Document type: Journal article
Source: Tetrahedron Letters; v. 52, n. 51, p. 6883-6886, DEC 21 2011.
Web of Science Citations: 5
Abstract

A series of 2-(S)-isopropyl-pyrimidinones functionalized at C5 with triazole rings, in which the substituents are found at N-1' of the triazole ring, were synthesized. Through the azide-acetylene cycloaddition reaction, using Cul as a copper source and ultrasonic waves as an energy source it was possible to obtain products with yields ranging from 79% to 89% within 5 min or less. A preliminary study to gain further insight into the reaction was performed using in situ ReactIR technology. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/15677-8 - Synthesis of alpha-substituted styrenes
Grantee:Flávia Giovana Manarin
Support Opportunities: Scholarships in Brazil - Post-Doctoral