| Full text | |
| Author(s): Show less - |
Amps, Katherine
[1]
;
Andrews, Peter W.
[1]
;
Anyfantis, George
[2]
;
Armstrong, Lyle
[2]
;
Avery, Stuart
[3]
;
Baharvand, Hossein
[4]
;
Baker, Julie
[5]
;
Baker, Duncan
[6]
;
Munoz, Maria B.
[7]
;
Beil, Stephen
[8]
;
Benvenisty, Nissim
[9]
;
Ben-Yosef, Dalit
[10, 11]
;
Biancotti, Juan-Carlos
[12]
;
Bosman, Alexis
[13]
;
Brena, Romulo Martin
[14]
;
Brison, Daniel
[15]
;
Caisander, Gunilla
[16]
;
Camarasa, Maria V.
[17]
;
Chen, Jieming
[18]
;
Chiao, Eric
[5, 19]
;
Choi, Young Min
[20]
;
Choo, Andre B. H.
[21]
;
Collins, Daniel
[22]
;
Colman, Alan
[3, 23]
;
Crook, Jeremy M.
[3, 23, 24, 25, 26]
;
Daley, George Q.
[27, 28, 29, 30, 31]
;
Dalton, Anne
[6]
;
De Sousa, Paul A.
[22, 32]
;
Denning, Chris
[7]
;
Downie, Janet
[22]
;
Dvorak, Petr
[33]
;
Montgomery, Karen D.
[34]
;
Feki, Anis
[35]
;
Ford, Angela
[1]
;
Fox, Victoria
[8]
;
Fraga, Ana M.
[36]
;
Frumkin, Tzvia
[10]
;
Ge, Lin
[37]
;
Gokhale, Paul J.
[1]
;
Golan-Lev, Tamar
[9]
;
Gourabi, Hamid
[4]
;
Gropp, Michal
[38]
;
Guangxiu, Lu
[39]
;
Hampl, Ales
[40, 41]
;
Harron, Katie
[42]
;
Healy, Lyn
[43]
;
Herath, Wishva
[18]
;
Holm, Frida
[44]
;
Hovatta, Outi
[44]
;
Hyllner, Johan
[16]
;
Inamdar, Maneesha S.
[45]
;
Irwanto, Astrid Kresentia
[18]
;
Ishii, Tetsuya
[46]
;
Jaconi, Marisa
[13]
;
Jin, Ying
[47]
;
Kimber, Susan
[17]
;
Kiselev, Sergey
[48, 49]
;
Knowles, Barbara B.
[3]
;
Kopper, Oded
[9]
;
Kukharenko, Valeri
[50]
;
Kuliev, Anver
[50]
;
Lagarkova, Maria A.
[49]
;
Laird, Peter W.
[14]
;
Lako, Majlinda
[2]
;
Laslett, Andrew L.
[51, 52]
;
Lavon, Neta
[12]
;
Lee, Dong Ryul
[53]
;
Lee, Jeoung Eun
[39]
;
Li, Chunliang
[54]
;
Lim, Linda S.
[18]
;
Ludwig, Tenneille E.
[34]
;
Ma, Yu
[54]
;
Maltby, Edna
[6]
;
Mateizel, Ileana
[55]
;
Mayshar, Yoav
[9]
;
Mileikovsky, Maria
[56]
;
Minger, Stephen L.
[57, 58]
;
Miyazaki, Takamichi
[59]
;
Moon, Shin Yong
[20]
;
Moore, Harry
[1]
;
Mummery, Christine
[60]
;
Nagy, Andras
[56]
;
Nakatsuji, Norio
[61]
;
Narwani, Kavita
[12]
;
Oh, Steve K. W.
[21]
;
Oh, Sun Kyung
[62]
;
Olson, Cia
[63]
;
Otonkoski, Timo
[63, 64, 65]
;
Pan, Fei
[14]
;
Park, In-Hyun
[66]
;
Pells, Steve
[32]
;
Pera, Martin F.
[39]
;
Pereira, Lygia V.
[36]
;
Qi, Ouyang
[39]
;
Raj, Grace Selva
[23]
;
Reubinoff, Benjamin
[38]
;
Robins, Alan
[67]
;
Robson, Paul
[18]
;
Rossant, Janet
[68]
;
Salekdeh, Ghasem H.
[69]
;
Schulz, Thomas C.
[67]
;
Sermon, Karen
[55]
;
Mohamed, Jameelah Sheik
[18]
;
Shen, Hui
[14]
;
Sherrer, Eric
[67]
;
Sidhu, Kuldip
[70]
;
Sivarajah, Shirani
[23, 24, 25]
;
Skottman, Heli
[71]
;
Spits, Claudia
[55]
;
Stacey, Glyn N.
[43]
;
Strehl, Raimund
[16]
;
Strelchenko, Nick
[50]
;
Suemori, Hirofumi
[59]
;
Sun, Bowen
[54]
;
Suuronen, Riitta
[71]
;
Takahashi, Kazutoshi
[46]
;
Tuuri, Timo
[63]
;
Venu, Parvathy
[45]
;
Verlinsky, Yuri
[50]
;
Ward-van Oostwaard, Dorien
[60]
;
Weisenberger, Daniel J.
[14]
;
Wu, Yue
[57, 58]
;
Yamanaka, Shinya
[46, 61, 72, 73]
;
Young, Lorraine
[7]
;
Zhou, Qi
[51]
;
Initiative, Int Stem Cell
[39]
Total Authors: 126
|
| Affiliation: Show less - | [1] Univ Sheffield, Dept Biomed Sci, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire - England
[2] Int Ctr Life, NE England Stem Cell Inst Life, Newcastle Upon Tyne, Tyne & Wear - England
[3] ASTAR, Inst Med Biol, Immunos - Singapore
[4] Royan Inst Reprod Biomed, Dept Genet, Tehran - Iran
[5] Stanford Univ, Stanford, CA 94305 - USA
[6] Sheffield Childrens NHS Trust, Sheffield Diagnost Genet Serv, Sheffield, S Yorkshire - England
[7] Univ Nottingham, Ctr Biomol Sci, Wolfson Ctr Stem Cells Tissue Engn & Modelling ST, Nottingham NG7 2RD - England
[8] Univ So Calif, Keck Sch Med, USC Stem Cell Core Facil, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90033 - USA
[9] Hebrew Univ Jerusalem, Dept Genet, Alexander Silberman Inst Life Sci, Stem Cell Unit, IL-91904 Jerusalem - Israel
[10] Lis Matern Hosp, Tel Aviv Sourasky Med Ctr, Racine IVF Unit, Tel Aviv - Israel
[11] Tel Aviv Univ, Sackler Fac Med, Dept Cell Dev Biol, IL-69978 Tel Aviv - Israel
[12] Cedars Sinai Med Inst, Regenerat Med Inst, Los Angeles, CA - USA
[13] Univ Geneva, Fac Med, Dept Pathol & Immunol, Geneva - Switzerland
[14] Univ So Calif, Keck Sch Med, USC Epigenome Ctr, Los Angeles, CA 90033 - USA
[15] Cent Manchester NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, St Maryss Hosp, Dept Reprod Med, Manchester, Lancs - England
[16] Cellartis AB, Gothenburg - Sweden
[17] Univ Manchester, Fac Life Sci, Manchester, Lancs - England
[18] Genome Inst Singapore, Singapore - Singapore
[19] Hoffmann LaRoche, Nutley, NJ - USA
[20] Seoul Natl Univ, Coll Med, Dept Obstet & Gynaecol, Seoul - South Korea
[21] Bioproc Technol Inst, Singapore - Singapore
[22] Roslin Cells Ltd, Roslin Bioctr, Roslin, Midlothian - Scotland
[23] ASTAR, Singapore Stem Cell Consortium, Singapore - Singapore
[24] Univ Melbourne, Ctr Neural Engn, Parkville, Vic 3052 - Australia
[25] Univ Melbourne, Opt & Nanoelect Res Grp, NICTA Victorian Res Lab, Parkville, Vic 3052 - Australia
[26] Univ Melbourne, St Vincents Hosp, Dept Surg, Fitzroy, Vic 3065 - Australia
[27] Childrens Hosp, Howard Hughes Med Inst, Stem Cell Transplantat Program, Div Pediat Hematol Oncol, Manton Ctr Orphan Dis Re, Boston, MA 02115 - USA
[28] Dana Farber Canc Inst, Boston, MA 02115 - USA
[29] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 - USA
[30] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 - USA
[31] Harvard Stem Cell Inst, Boston, MA - USA
[32] Univ Edinburgh, MRC, Ctr Regenerat Med, Edinburgh, Midlothian - Scotland
[33] Masaryk Univ, Dept Biol, Fac Med, Brno - Czech Republic
[34] WiCell Res Inst, Madison, WI - USA
[35] Hop Cantonal Fribourgois, Dept Obstet & Gynecol, Freibourg - Switzerland
[36] Univ Sao Paulo, Dept Genet & Evolutionary Biol, Natl Lab Embryon Stem Cell Res LaNCE, Sao Paulo - Brazil
[37] Cent S Univ, Inst Reprod & Stem Cell Engn, Reprod & Genet Hosp CITIC XIANGYA, Changsha, Hunan - Peoples R China
[38] Hadassah Univ, Med Ctr, Goldyne Savad Inst Gene Therapy, Hadassah Human Embryon Stem Cell Res Ctr, Jerusalem - Israel
[39] Lu Guangxiu, Cent S Univ, Inst Reprod & Stem Cell Engn, Reprod & Genet Hosp CITIC XIANGYA, Changsha, Hunan - Peoples R China
[40] Masaryk Univ, Fac Med, Dept Histol & Embryol, Brno - Czech Republic
[41] Inst Expt Med ASCR, Prague - Czech Republic
[42] UCL, Inst Child Hlth, MRC Ctr Epidemiol Child Hlth, London - England
[43] Natl Inst Biol Stand & Controls, Div Cell Biol & Imaging, UK Stem Cell Bank, S Mimms, Herts - England
[44] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm - Sweden
[45] Indian Inst Sci, Jawaharlal Nehru Ctr Adv Sci Res, Bangalore 560012, Karnataka - India
[46] Kyoto Univ, Ctr iPS Cell Res & Applicat CiRA, Kyoto - Japan
[47] CAS Shanghai Jiao Tong Univ, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol, Inst Hlth Sci, Sch Med, Shanghai - Peoples R China
[48] NRC Kurchatov Inst, Stem Cell Dept, Moscow - Russia
[49] Vavilov Inst Gen Genet, Moscow - Russia
[50] Illinois Masonic Med Ctr, Inst Reprod Genet, Chicago, IL 60657 - USA
[51] CSIRO Mat Sci & Engn, Clayton, Vic - Australia
[52] Monash Univ, Dept Anat & Dev Biol, Clayton, Vic - Australia
[53] CHA Univ, CHA Stem Cell Inst, Dept Biomed Sci, Seoul - South Korea
[54] Shanghai Jiao Tong Univ, Sch Med, Shanghai Stem Cell Inst, Shanghai 200030 - Peoples R China
[55] Vrije Univ Brussel, Dept Embryol & Genet, Brussels - Belgium
[56] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5 - Canada
[57] Kings Coll London, Wolfson Ctr Age Related Dis, London WC2R 2LS - England
[58] GE Healthcare, Cardiff, S Glam - Wales
[59] Kyoto Univ, Inst Frontier Med Sci, Stem Cell Res Ctr, Lab Embryon Stem Cell Res, Kyoto - Japan
[60] Leiden Univ, Med Ctr, Dept Anat & Embryol, Leiden - Netherlands
[61] Kyoto Univ, Inst Integrated Cell Mat Sci, Sakyo Ku, Kyoto - Japan
[62] Seoul Natl Univ, Med Res Ctr, Inst Reprod Med & Populat, Seoul - South Korea
[63] Univ Helsinki, Res Programs Unit, Biomedicum Stem Cell Ctr, FIN-00014 Helsinki - Finland
[64] Univ Helsinki, Childrens Hosp, FIN-00014 Helsinki - Finland
[65] Univ Helsinki, Cent Hosp, FIN-00014 Helsinki - Finland
[66] Yale Univ, Sch Med, Dept Genet, Yale Stem Cell Ctr, New Haven, CT 06510 - USA
[67] Viacyte, Athens, GA - USA
[68] Hosp Sick Children, Program Dev Biol, Toronto, ON M5G 1X8 - Canada
[69] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Mol Syst Biol, Tehran - Iran
[70] Univ New S Wales, Fac Med, Stem Cell Lab, Sydney, NSW 2052 - Australia
[71] Univ Tampere, Inst Regenerat Med, FIN-33101 Tampere - Finland
[72] Japan Sci & Technol Agcy, Yamanaka iPS Cell Special Project, Kawaguchi, Saitama - Japan
[73] Gladstone Inst Cardiovasc Dis, San Francisco, CA - USA
Total Affiliations: 73
|
| Document type: | Journal article |
| Source: | NATURE BIOTECHNOLOGY; v. 29, n. 12, p. 1132-U113, DEC 2011. |
| Web of Science Citations: | 280 |
| Abstract | |
The International Stem Cell Initiative analyzed 125 human embryonic stem (ES) cell lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for genetic changes occurring during culture. Most lines were analyzed at an early and late passage. Single-nucleotide polymorphism (SNP) analysis revealed that they included representatives of most major ethnic groups. Most lines remained karyotypically normal, but there was a progressive tendency to acquire changes on prolonged culture, commonly affecting chromosomes 1, 12, 17 and 20. DNA methylation patterns changed haphazardly with no link to time in culture. Structural variants, determined from the SNP arrays, also appeared sporadically. No common variants related to culture were observed on chromosomes 1, 12 and 17, but a minimal amplicon in chromosome 20q11.21, including three genes expressed in human ES cells, ID1, BCL2L1 and HM13, occurred in >20% of the lines. Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells. (AU) | |