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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chronic fluoxetine treatment alters cardiovascular functions in unanesthetized rats

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Author(s):
Crestani, Carlos C. [1] ; Tavares, Rodrigo F. [2] ; Guimaraes, Franscisco S. [2] ; Correa, Fernando M. A. [2] ; Joca, Samia R. L. [3] ; Resstel, Leonardo B. M. [2]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci Araraquara, Dept Nat Act Principles & Toxicol, BR-14801902 Sao Paulo - Brazil
[2] USP, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil
[3] USP, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: European Journal of Pharmacology; v. 670, n. 2-3, p. 527-533, NOV 30 2011.
Web of Science Citations: 26
Abstract

In the present study, we investigated the effects induced by fluoxetine treatment (10 mg/kg) for either 1 or 21 consecutive days on arterial pressure and heart rate basal levels, baroreflex activity, hemodynamic responses to vasoactive agents and cardiovascular responses to acute restraint stress. Mild hypertension was observed after 21 days of treatment, but not after administration for 1 day. Moreover, chronic treatment affected the baroreflex control of heart rate, which was characterized by a reduced reflex tachycardia and an enhanced bradycardiac baroreflex response. The pressor responses to systemic administration of the selective alpha(1)-adrenoceptor agonist phenylephrine, as well as the depressor responses to systemic infusion of the nitric oxide donor sodium nitroprusside, were reduced after chronic fluoxetine treatment. Fluoxetine treatment for 21 days reduced both the pressor and tachycardiac responses evoked by acute restraint stress. In conclusion, the results indicate the development of mild hypertension after chronic fluoxetine treatment. This effect was followed by changes in the baroreflex control of heart rate and altered vascular responsiveness to pressor and depressor agents, which may explain, at least in part, the increase in arterial pressure. Chronic fluoxetine treatment also affected cardiovascular responses to restraint stress, thus indicating that fluoxetine may affect cardiovascular adaptation under conditions of stress. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/07332-3 - Possible role of dorsal hippocampus on behaviour and autonomic responses during defensive responses: involvement of NMDA receptor/nitric oxide and endocanabinoid
Grantee:Leonardo Resstel Barbosa Moraes
Support Opportunities: Regular Research Grants
FAPESP's process: 10/16192-8 - Cardiovascular effects of chronic administration of cocaine and testosterone in rats
Grantee:Carlos Cesar Crestani
Support Opportunities: Regular Research Grants