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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Uniqueness of the Trypanosoma cruzi Mitochondrion: Opportunities to Target New Drugs Against Chagas' Disease

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Author(s):
Paes, Lisvane Silva [1] ; Mantilla, Brian Suarez [1] ; Barison, Maria Julia [1] ; Wrenger, Carsten [1] ; Silber, Ariel Mariano [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: CURRENT PHARMACEUTICAL DESIGN; v. 17, n. 20, p. 2074-2099, JUL 2011.
Web of Science Citations: 15
Abstract

Trypanosoma cruzi is the causative agent of Chagas' disease, which affects some 8 - 10 million people in the Americas. The only two drugs approved for the etiological treatment of the disease in humans were launched more than 40 years ago and have serious drawbacks. In the present work, we revisit the unique characteristics of T. cruzi mitochondria and mitochondrial metabolism. The possibility of taking advantage of these peculiarities to target new drugs against this parasite is also discussed. (AU)