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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Glatiramer Acetate Treatment Increases Stability of Spinal Synapses and Down Regulates MHC I during the Course of EAE

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Author(s):
Scorisa, Juliana M. [1] ; Freria, Camila M. [1] ; Victorio, Sheila C. [1] ; Barbizan, Roberta [1] ; Zanon, Renata G. [1, 2] ; Oliveira, Alexandre L. R. [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Inst Biol, Dept Anat Cell Biol Physiol & Biophys, Campinas, SP - Brazil
[2] UFU, Human Anat Sect, Dept Morphol, Campus Umuarama - Brazil
Total Affiliations: 2
Document type: Journal article
Source: International Journal of Biological Sciences; v. 7, n. 8, p. 1188-1202, 2011.
Web of Science Citations: 7
Abstract

The recent discovery that the major histocompatibility complex of class I (MHC I) expression has a role in the synaptic elimination process, represented an insight into understanding the cross talk between neurons. In the present study, the possibility that glatiramer acetate (GA) treatment influences the MHC class I expression and the synaptic plasticity process in the spinal cord during the course of EAE was investigated. C57BL/6J mice were induced to EAE and submitted to treatment either with a placebo solution or with GA (0.05mg/animal, subcutaneously, on a daily basis). All the animals were sacrificed at the peak disease (14 days after induction) or at the point of recovery of the clinical signs (21 days after induction). The spinal cords were removed and submitted to immunohistochemical examination, Western blotting and transmission electron microscopy analysis. The results showed that GA treatment was able to decrease synaptic loss during the course of EAE, which correlates with the downregulation of the MHC I complex. The present results reinforce the neuroprotective role of GA treatment, by reducing synaptic loss during the course of the disease. Such action may be associated with the recently described role of MHC I regulation during the synaptic plasticity process. (AU)

FAPESP's process: 11/18991-8 - Glatiramer acetate treatment increases stability of spinal synapses and down regulates MHC I during the course of EAE
Grantee:Alexandre Leite Rodrigues de Oliveira
Support Opportunities: Regular Research Grants - Publications - Scientific article