Tormena, Claudio F.
Morris, Gareth A.
Total Authors: 5
 Univ Estadual Campinas, Inst Chem, BR-13094971 Sao Paulo - Brazil
 Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs - England
 Givaudan, Dept Analyt Res, NL-1411 GP Naarden - Netherlands
Total Affiliations: 3
Magnetic Resonance in Chemistry;
Web of Science Citations:
The component spectra of a mixture of isomers with nearly identical diffusion coefficients cannot normally be distinguished in a standard diffusion-ordered spectroscopy (DOSY) experiment but can often be easily resolved using matrix-assisted DOSY, in which diffusion behaviour is manipulated by the addition of a co-solute such as a surfactant. Relatively little is currently known about the conditions required for such a separation, for example, how the choice between normal and reverse micelles affects separation or how the isomer structures themselves affect the resolution. The aim of this study was to explore the application of sodium dodecyl sulfate (SDS) normal micelles in aqueous solution and sodium 1,4-bis(2-ethylhexyl)sulfosuccinate (AOT) aggregates in chloroform, at a range of concentrations, to the diffusion resolution of some simple model sets of isomers such as monomethoxyphenols and short chain alcohols. It is shown that SDS micelles offer better resolution where these isomers differ in the position of a hydroxyl group, whereas AOT aggregates are more effective for isomers differing in the position of a methyl group. For both the normal SDS micelles and the less well-defined AOT aggregates, differences in the resolution of the isomers can in part be rationalised in terms of differing degrees of hydrophobicity, amphiphilicity and steric effects. Copyright (c) 2012 John Wiley \& Sons, Ltd. (AU)