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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility

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Matos, Gabriela [1] ; Scorza, Fulvio A. [2] ; Cavalheiro, Esper A. [2] ; Tufik, Sergio [1] ; Andersen, Monica L. [1]
Total Authors: 5
[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Disciplina Neurol Expt, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: Journal of Sexual Medicine; v. 9, n. 8, p. 2111-2121, AUG 2012.
Web of Science Citations: 9

Introduction. There is a high prevalence of erectile dysfunction (ED) in men with epilepsy; however, few studies have been conducted concerning the treatment of ED in this neurological group. Aim. The main purpose of this review is to highlight the influence of phosphodiesterase type 5 inhibitor (PDEI-5) for ED on seizure susceptibility. Methods. All available online articles with information pertaining to PDEI-5 and seizure susceptibility were included in this review. Main Outcome Measures. The main outcome assessed demonstrated the intriguing role of PDEI-5 and its metabolites on seizure susceptibility. Results. Case reports in men without epilepsy described seizure occurrence and electrophysiological changes following sildenafil, tadalafil, or vardenafil treatment. Consistent with these findings, preclinical studies suggested a proconvulsant effect of PDEI-5 on models of seizure induction. Conclusions. Evidence suggests an influence of PDEI-5 on seizure susceptibility in humans. In addition, preclinical studies have demonstrated the role of nitric oxide metabolites in the facilitation of paroxysmal phenomenon. Although there are many causes of seizures, medical professionals should be aware of the possible influence of PDEI-5 on seizure susceptibility. Further investigation by physicians and scientists is required to improve our understanding of this important topic. Matos G, Scorza FA, Cavalheiro EA, Tufik S, and Andersen ML. PDEI-5 for erectile dysfunction: A potential role in seizure susceptibility. J Sex Med 2012;9:21112121. (AU)

FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 10/15110-8 - Sleep and sudden unexpected death in epilepsy: possible molecular basis?
Grantee:Gabriela de Matos Barbosa Pimenta
Support type: Scholarships in Brazil - Post-Doctorate