Reduced muscle carnosine content in type 2, but not in type 1 diabetic patients

Author(s):Show less -

Gualano, Bruno ^[1] ; Everaert, Inge ^[2] ; Stegen, Sanne ^[2] ; Artioli, Guilherme Giannini ^[1] ; Taes, Youri ^[3] ; Roschel, Hamilton ^[1] ; Achten, Eric ^[4] ; Otaduy, Maria Concepcion ^[5] ; Lancha Junior, Antonio Herbert ^[1] ; Harris, Roger ^[1] ; Derave, Wim ^[2]

Affiliation

^[1] Univ Sao Paulo, Sch Phys Educ & Sports, Dept Biodynam Human Movement, BR-05508030 Sao Paulo - Brazil

^[2] Univ Ghent, Dept Movement & Sports Sci, B-9000 Ghent - Belgium

^[3] Ghent Univ Hosp, Dept Endocrinol, Ghent - Belgium

^[4] Univ Ghent, Dept Radiol & Nucl Med, Ghent Inst Funct & Metab Imaging GIfMI, B-9000 Ghent - Belgium

^[5] Univ Sao Paulo, Dept Radiol, Sch Med, BR-05508030 Sao Paulo - Brazil

• Document type: Journal article
• Source: Amino Acids; v. 43, n. 1, p. 21-24, JUL 2012.
• Web of Science Citations: 24

Abstract

Carnosine is present in high concentrations in skeletal muscle where it contributes to acid buffering and functions also as a natural protector against oxidative and carbonyl stress. Animal studies have shown an anti-diabetic effect of carnosine supplementation. High carnosinase activity, the carnosine degrading enzyme in serum, is a risk factor for diabetic complications in humans. The aim of the present study was to compare the muscle carnosine concentration in diabetic subjects to the level in non-diabetics. Type 1 and 2 diabetic patients and matched healthy controls (total n = 58) were included in the study. Muscle carnosine content was evaluated by proton magnetic resonance spectroscopy (3 Tesla) in soleus and gastrocnemius. Significantly lower carnosine content (-45%) in gastrocnemius muscle, but not in soleus, was shown in type 2 diabetic patients compared with controls. No differences were observed in type 1 diabetic patients. Type II diabetic patients display a reduced muscular carnosine content. A reduction in muscle carnosine concentration may be partially associated with defective mechanisms against oxidative, glycative and carbonyl stress in muscle. (AU)

• FAPESP's process: 05/56464-9 - Neuroscience Imaging Center at University of São Paulo Medical School
• Grantee: Giovanni Guido Cerri
• Support Opportunities: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants
• FAPESP's process: 10/11221-0 - Artificial elevation of muscle buffering capacity: effects upon muscle performance and function and underlying mechanisms
• Grantee: Antonio Herbert Lancha Junior
• Support Opportunities: Regular Research Grants