| Full text | |
| Author(s): |
Matos, Marinez F.
[1]
;
Lourenco, Dayse M.
[1]
;
Orikaza, Cristina M.
[1]
;
Bajerl, Joao A. H.
[1]
;
Noguti, Maria A. E.
[1]
;
Morelli, Vania M.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Fed Sao Paulo, Hematol & Hemotherapy Serv, UNIFESP, BR-04023900 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | THROMBOSIS RESEARCH; v. 128, n. 3, p. 216-220, SEP 2011. |
| Web of Science Citations: | 29 |
| Abstract | |
Introduction: Cytokines increased the risk of venous thromboembolism (VTE) in some case-control studies, but not in a prospective study. Data concerning the role of cytokines in the risk of VTE are limited. We examined in a case-control study the association of VTE and levels of interleukin (IL)-6, IL-8 and monocyte chemotactic protein-1 (MCP-1) and assessed whether promoter polymorphisms (IL-6 -174GC, IL-8 -251AT, MCP-1 -2518AG) would affect the thrombotic risk and cytokine levels. Materials and methods: The study included 119 patients (94 women) with a first event of VTE aged between 18-60 years, and 126 healthy controls (100 women) matched for age (+/- 5 years). Blood was collected >7 months after the thrombotic event. Odds ratios (ORs) were calculated per increase of cytokines levels by 1 pg/mL. Results: ORs adjusted for age and sex were 1.520 {[}95% Confidence Interval (CI) 1.177 - 1.962] for IL-6, 1.095 (95% CI 1.002 - 1.196) for IL-8 and 1.000 (0.988 - 1.012) for MCP-1. With additional adjustment for ethnic composition, body mass index (BMI) and high sensitive C-reactive protein (hs-CRP), risk estimates remained significant for IL-6 and became of borderline statistical significance for IL-8. Polymorphisms did not influence the thrombotic risk and the cytokine levels in study participants. Conclusion: VTE was associated with IL-6 and IL-8 levels, and for IL-6 this association was independent of BMI and hs-CRP. Thus far, a causal relationship between inflammation and VTE remains to be clarified and more prospective data are warranted. (C) 2011 Elsevier Ltd. All rights reserved. (AU) | |