| Full text | |
| Author(s): |
Fernandes, Tiago
[1]
;
Hashimoto, Nara Y.
[1]
;
Magalhaes, Flavio C.
[1]
;
Fernandes, Fernanda B.
[2]
;
Casarini, Dulce E.
[2]
;
Carmona, Adriana K.
[3]
;
Krieger, Jose E.
[4]
;
Phillips, M. Ian
[5]
;
Oliveira, Edilamar M.
[1, 5]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Biochem & Mol Biol Exercise, BR-05508900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Div Nephrol, Kidney & Hypertens Hosp, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, InCor, Lab Genet & Mol Cardiol, BR-05508900 Sao Paulo - Brazil
[5] Keck Grad Inst, Lab Stem Cells, Claremont, CA - USA
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Hypertension; v. 58, n. 2, p. 182-U121, AUG 2011. |
| Web of Science Citations: | 99 |
| Abstract | |
Aerobic exercise training leads to a physiological, nonpathological left ventricular hypertrophy; however, the underlying biochemical and molecular mechanisms of physiological left ventricular hypertrophy are unknown. The role of microRNAs regulating the classic and the novel cardiac renin-angiotensin (Ang) system was studied in trained rats assigned to 3 groups: (1) sedentary; (2) swimming trained with protocol 1 (T1, moderate-volume training); and (3) protocol 2 (T2, high-volume training). Cardiac Ang I levels, Ang-converting enzyme (ACE) activity, and protein expression, as well as Ang II levels, were lower in T1 and T2; however, Ang II type 1 receptor mRNA levels (69% in T1 and 99% in T2) and protein expression (240% in T1 and 300% in T2) increased after training. Ang II type 2 receptor mRNA levels (220%) and protein expression (332%) were shown to be increased in T2. In addition, T1 and T2 were shown to increase ACE2 activity and protein expression and Ang (1-7) levels in the heart. Exercise increased microRNA-27a and 27b, targeting ACE and decreasing microRNA-143 targeting ACE2 in the heart. Left ventricular hypertrophy induced by aerobic training involves microRNA regulation and an increase in cardiac Ang II type 1 receptor without the participation of Ang II. Parallel to this, an increase in ACE2, Ang (1-7), and Ang II type 2 receptor in the heart by exercise suggests that this nonclassic cardiac renin-angiotensin system counteracts the classic cardiac renin-angiotensin system. These findings are consistent with a model in which exercise may induce left ventricular hypertrophy, at least in part, altering the expression of specific microRNAs targeting renin-angiotensin system genes. Together these effects might provide the additional aerobic capacity required by the exercised heart. (Hypertension. 2011;58:182-189.). (AU) | |
| FAPESP's process: | 07/56771-4 - Efeitos do treinamento fisico aerobico na modulacao das celulas progenitoras endoteliais derivadas da medula ossea em ratos espontaneamente hipertensos (shr) |
| Grantee: | Tiago Fernandes |
| Support Opportunities: | Scholarships in Brazil - Master |