Deregulated expression of superoxide dismutase-2 correlates with different stages of cervical neoplasia

Author(s)

Termini, Lara ^{[1, 2]} ; Longatto Filho, Adhemar ^{[3, 4]} ; Maciag, Paulo Cesar ^[2] ; Etlinger, Daniela ^[5] ; Ferreira Alves, Venancio Avancini ^[4] ; Nonogaki, Suely ^[5] ; Soares, Fernando Augusto ^{[6, 7]} ; Villa, Luisa Lina ^[2]

Affiliation

^[1] Hosp Alemao Oswaldo Cruz, Ludwig Inst Canc Res, Virol Lab, BR-01323903 Sao Paulo - Brazil

^[2] INCT HPV, HPV Inst, Sao Paulo - Brazil

^[3] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst, Braga - Portugal

^[4] Univ Sao Paulo, Sch Med, Dept Pathol, Lab Med Invest LIM 14, Sao Paulo - Brazil

^[5] Adolfo Lutz Inst, Div Pathol, Sao Paulo - Brazil

^[6] Hosp AC Camargo Fund Antonio Prudente, Dept Anat Pathol, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Fac Dent, Dept Gen Pathol, Sao Paulo - Brazil

• Document type: Journal article
• Source: DISEASE MARKERS; v. 30, n. 6, p. 275-281, 2011.
• Web of Science Citations: 8

Abstract

Objective: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer. Methods: In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO). Results: We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining. Conclusions: Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease. (AU)