Serum melatonin level and oxidative stress in sickle cell anemia

Author(s)

Tomimatsu Shimauti, Eliana Litsuko ^{[1, 2]} ; Humberto Silva, Danilo Grunig ^{[3, 1]} ; de Almeida, Eduardo Alves ^[3] ; Antoniazzo Zamaro, Paula Juliana ^[1] ; Belini Junior, Edis ^[1] ; Bonini-Domingos, Claudia Regina ^[1]

Affiliation

^[1] Sao Paulo State Univ, UNESP, Hemoglobin & Hematol Genet Dis Lab, Dept Biol, Sao Paulo - Brazil

^[2] Univ Estadual Maringa, UEM, Dept Clin Anal, Maringa, Parana - Brazil

^[3] Sao Paulo State Univ, UNESP, Dept Chem & Environm Sci, Sao Paulo - Brazil

• Document type: Journal article
• Source: BLOOD CELLS MOLECULES AND DISEASES; v. 45, n. 4, p. 297-301, DEC 15 2010.
• Web of Science Citations: 11

Abstract

This study evaluated serum melatonin levels in patients with sickle cell anemia (SCA) and compared the results to lipid peroxidation by determining thiobarbituric acid-reactive substances (TBARS) and Trolox equivalent antioxidant capacity (TEAC). The group studied was composed of 15 SCA patients and 24 subjects without hemoglobinopathies. The average melatonin level was significantly reduced in the SCA patients (p<0.001) when compared to the control group. The SCA patients showed significantly higher values for TBARS and TEAC when compared to values obtained for the control group (p<0.001 and p<0.01). Results from the correlation analysis in the SCA group were not statistically significant for any parameters except for TBARS and TEAC levels, which had a positive correlation (r = 0.51; p = 0.04), suggesting the participation of melatonin in antioxidant defense. The use of melatonin could be a possible therapeutic target for improving antioxidant defense and to reduce oxidative damage, alleviating symptoms associated with SCA. (C) 2010 Elsevier Inc. All rights reserved. (AU)