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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture

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Author(s):
Botelho, Adriana Prais [1] ; Santos-Zago, Lilia Ferreira [1, 2] ; de Oliveira, Admar Costa [3]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, Fac Engn Alimentos, Programa Doutorado Alimentos & Nutr, Dept Alimentos & Nutr, BR-13083862 Campinas, SP - Brazil
[2] Pontificia Univ Catolica Campinas, Ctr Ciencias Vida, Fac Nutr, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Fac Engn Alimentos, Dept Alimentos & Nutr, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REVISTA DE NUTRICAO-BRAZILIAN JOURNAL OF NUTRITION; v. 22, n. 5, p. 767-771, SEP-OCT 2009.
Web of Science Citations: 3
Abstract

Supplementation with conjugated linoleic acid may reduce fat body mass and increase lean body mass in various species. Some studies have demonstrated that conjugated linoleic acid reduces body fat, in part, by inhibiting the activity of lipoprotein lipase in adipocytes. The objective of this work was to study the effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture. 3T3-L1 adipocytes received linoleic acid (group C) or conjugated linoleic acid (group AE, supplemented with AdvantEdge® CLA, and group CO, supplemented with CLA One®) in concentrations of 1 mmol/L. Heparin-releasable lipoprotein lipase activity was analyzed by means of a 3T3-L1 adipocyte culture. After 7 days, heparin-releasable lipoprotein lipase activity was lower in the groups AE and CO supplemented with conjugated linoleic acid. These results suggest that one of the mechanisms by which CLA is capable of reducing body fat is by reducing lipoprotein lipase activity. (AU)