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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fonsecaea pedrosoi infection induces differential modulation of costimulatory molecules and cytokines in monocytes from patients with severe and mild forms of chromoblastomycosis

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Teixeira Sousa, Maria Gloria [1] ; Pedrozo e Silva Azevedo, Conceicao de Maria [2] ; Nascimento, Rosana Cicera [1] ; Bou Ghosn, Eliver Eid [1] ; Santiago, Karla Leticia [1] ; Noal, Vanessa [1] ; Bomfim, Gisele Facholi [1] ; Marques, Sirlei Garcia [2] ; Goncalves, Azizedite Guedes [2] ; Lima Santos, Daniel Wagner de Castro [2] ; Almeida, Sandro Rogerio [2]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508900 Sao Paulo - Brazil
[2] Univ Fed Maranhao, Dept Patol, Sao Luis Maranhao - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Leukocyte Biology; v. 84, n. 3, p. 864-870, SEP 1 2008.
Web of Science Citations: 8
Abstract

The host defense mechanism in chromoblastomycosis has not been thoroughly investigated. It has been suggested that cell- mediated immunity in patients with long- standing chromoblastomycosis is somehow impaired. As a result, these individuals became unable to develop an efficient immune reaction. Many studies have shown that monocyte- derived macrophages exhibit critical activities in immunity to microorganisms. Moreover, the ability of cells from the monocytic lineage to process and present antigens, to produce cytokines, and to provide costimulatory signals confirms their pivotal role in the initiation of specific immune responses. In the present study, it was observed that monocytes from patients with a severe form of disease had a higher production of IL- 10 and a lower expression of HLA- DR and costimulatory molecules when stimulated with specific antigen or LPS. Immune modulation with recombinant IL- 12 or anti- IL- 10 can restore the antigen- specific Th1- type immune response in chromoblastomycosis patients by up- regulating HLA- DR and costimulatory molecules in monocytes. Therefore, our data show that monocytes from patients with different clinical forms of chromoblastomycosis present distinct phenotypic and functional profiles. This observation suggests possible mechanisms that control the T cell response and influence their role in the development of pathology. (AU)