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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lack of clastogenic/genotoxic effects of Baccharis dracunculifolia extract on Swiss mouse peripheral blood cells

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Author(s):
Andrade, N. S. [1] ; Perazzo, F. F. [2] ; Maistro, E. L. [3]
Total Authors: 3
Affiliation:
[1] Univ Jose Rosario Vellano, Genet Lab, Alfenas, MG - Brazil
[2] Univ Fed Amapa, Lab Pesquisa Farmacos, Macapa, AP - Brazil
[3] Univ Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Genetics and Molecular Research; v. 7, n. 4, p. 1414-1421, 2008.
Web of Science Citations: 5
Abstract

Baccharis dracunculifolia De Candole (DC) ( Asteraceae) is indigenous throughout southeastern Latin America and is used by local people in traditional medicine. This plant is known to be the source of resin for the highly valued Brazilian green propolis. As no information is available on the safety of high doses of B. dracunculifolia extract, we evaluated the mutagenic potential of high doses of this plant extract in vivo on peripheral blood cells of Swiss mice using the comet assay and the micronucleus test. The extract was administered by gavage at doses of 1000, 1500 and 2000 mg/kg body weight. Peripheral blood cell samples were collected 4 and 24 h after treatment for the comet assay (genotoxicity assay), and at 48 and 72 h for the micronucleus test (clastogenicity assay). The B. dracunculifolia extract was devoid of clastogenic/genotoxic activity at all doses. (AU)