A new dic(7;12)(p12.21;p12.2) and i(12)(q10) during the lymphoid blast crisis of patient with Ph plus chronic myeloid leukemia

Author(s)

de Oliveira, Fabio Morato ^{[1, 2]} ; Palma, Leonardo de Carvalho ^{[1, 2]} ; Falcao, Roberto Passetto ^{[1, 2]} ; Simoes, Belinda Pinto ^{[1, 2]}

Affiliation

^[1] Natl Inst Sci & Technol Stem Cell & Cell Therapy, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Div Hematol, Dept Internal Med, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: MEDICAL ONCOLOGY; v. 29, n. 4, p. 2332-2336, DEC 2012.
• Web of Science Citations: 1

Abstract

Chronic myelogenous leukemia (CML) is a common myeloproliferative disease that is characterized by the clonal expansion of marrow stem cells, and is associated with the Philadelphia chromosome. As the disease progresses, additional chromosome abnormalities may arise. The prognostic impact of secondary chromosomal abnormalities in CML is complex, heterogeneous, and sometimes related to previous treatment. Here, we describe a CML patient in lymphoid blast crisis associated with a new chromosomal abnormality identified, dic(7;12)(p12.21;p12.2) and i(12)(q10) using classical cytogenetics and spectral karyotype analysis. To the best of our knowledge, this is the first report of t(7;12)(p11.1;q11.1) and i(12)(q10) in a CML patient with lymphoid evolution. (AU)