Association of angiotensin-converting enzyme I gene I/D polymorphism with endometrial but not with ovarian cancer

Author(s)

Alves Correa-Noronha, Silvana Aparecida ^[1] ; Ribeiro de Noronha, Samuel Marcos ^[1] ; Alecrim, Cheryl ^[1] ; Mesquita, Adriana de Carvalho ^[1] ; da Silva Brito, Gabriela Soares ^[1] ; Junqueira, Michele Gilvana ^[1] ; Leite, Daniela Batista ^[1] ; de Carvalho, Cristina Valletta ^[1] ; Cotrim Guerreiro da Silva, Ismael Dale ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 Sao Paulo - Brazil

• Document type: Journal article
• Source: Gynecological Endocrinology; v. 28, n. 11, p. 889-891, NOV 2012.
• Web of Science Citations: 3

Abstract

Associations have been found between the angiotensin-converting enzyme insertion deletion (I/D) polymorphism (ACE I/D) and endometrial and epithelial ovarian cancer (EC and EOC, respectively). In this study, the following frequencies for each of three ACE polymorphisms, DD, ID, and II, respectively, were observed: in the EC group, 55, 24, and 21% versus the control group 39, 40, and 21% (p = 0.033{*}); in the EOC group 49, 36, and 15% versus the control group 49, 33, and 18% (p = 0.82). According to these allelic distributions, DD carriers are 2.0 times more likely than individuals carrying the ID or II genotypes to develop EC; therefore, the DD genotype seems to be protective against EC. In contrast, no association was observed between ACE (I/D) polymorphism with EOC. The ACE (I/D) polymorphism might play a role in the pathogenesis of EC and it should be considered when identifying genetic markers for EC. (AU)