Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents

Author(s):Show less -

de Piano, Aline ^[1] ; de Mello, Marco T. ^[2] ; Sanches, Priscila de L. ^[1] ; da Silva, Patricia L. ^[1] ; Campos, Raquel M. S. ^[1] ; Carnier, June ^[1] ; Corgosinho, Flavia ^[1] ; Foschini, Denis ^[1] ; Masquio, Deborah L. ^[3] ; Tock, Lian ^[1] ; Oyama, Lila M. ^[1] ; da Penha Oller do Nascimento, Claudia Maria ^[1] ; Tufik, Sergio ^[2] ; Damaso, Ana R. ^{[3, 1, 4]}

Affiliation

^[1] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Post Grad Program Nutr, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Psycobiol Dept, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Post Grad Program Interdisiciplinary Hlth Sci, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Dept Biosci, Sao Paulo - Brazil

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY; v. 24, n. 11, p. 1313-1324, NOV 2012.
• Web of Science Citations: 40

Abstract

Objective To compare the effects of aerobic training (AT) with aerobic plus resistance training (AT+RT) in nonalcoholic fatty liver disease (NAFLD) obese adolescents. Design Long-term interdisciplinary weight-loss therapy (1 year of clinical, nutritional, psychological, and exercise-related intervention). Participants Fifty-eight postpubertal obese adolescents were randomized to AT or AT+RT according to NAFLD diagnosis. Adipokine and neuropeptide concentrations were measured by enzyme-linked immunosorbent assay, visceral fat by ultrasound, and body composition by plethysmography. Results The NAFLD group that followed the AT+RT protocol presented lower insulin, homeostasis model assessment-insulin resistance (HOMA-IR), and alanine transaminase (ALT) values after intervention compared with AT. It was verified that there was a higher magnitude of change in the subcutaneous fat, glycemia, total cholesterol (TC), low-density lipoprotein-cholesterol, ALT, and adiponectin in response to AT+RT than in the control group (AT). All patients who underwent the AT+RT exhibited significantly higher adiponectin, leptin, and Delta adiponectin and lower melanin-concentrating hormone (MCH) concentrations after therapy compared with the AT group. In the simple linear regression analysis, changes in glycemia, insulin, and HOMA-IR were independent predictors of significant improvement in adiponectin concentration. Indeed, Delta AST (aspartate transaminase) and Delta GGT (gamma-glutamyl transpeptidase) were independent predictors of Delta ALT, while Delta fat mass and Delta AgRP (agouti-related protein) were independent predictors of Delta MCH. Although the number of patients was limited, we showed for the first time the positive effects of AT+RT protocol in a long-term interdisciplinary therapy to improve inflammatory biomarkers and to reduce orexigenic neuropeptide concentrations in NAFLD obese adolescents. Conclusion The long-term interdisciplinary therapy with AT+RT protocol was more effective in significantly improving noninvasive biomarkers of NAFLD that are associated with the highest risk of disease progression in the pediatric population. Eur J Gastroenterol Hepatol 24: 1313-1324 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins. (AU)

• FAPESP's process: 06/00684-3 - Orexigenic, anorexigenic, pro and pre-inflamatory factors: effects of a multidisciplinary program for weight reduction in obese adolescents
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants