| Full text | |
| Author(s): |
dos Santos Pinto, Jose R. A.
[1]
;
Fox, Eduardo G. P.
[2]
;
Saidemberg, Daniel M.
[1]
;
Santos, Lucilene D.
[1]
;
da Silva Menegasso, Anally R.
[1]
;
Costa-Manso, Eliude
[3]
;
Machado, Ednildo A.
[2]
;
Bueno, Odair C.
[1]
;
Palma, Mario S.
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo State UNESP, Dept Biol, Ctr Study Social Insects, Inst Biosci, Rio Claro, SP - Brazil
[2] Fed Univ Rio de Janeiro IBCCF UFRJ, Inst Biofis Carlos Chagas Filho, Lab Entomol Med & Mol, Rio De Janeiro - Brazil
[3] Clin Allergol, Pouso Alegre, MG - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | JOURNAL OF PROTEOME RESEARCH; v. 11, n. 9, p. 4643-4653, SEP 2012. |
| Web of Science Citations: | 40 |
| Abstract | |
Fire ants are well-known by their aggressive stinging behavior, causing many stinging incidents of medical importance. The limited availability of fire ant venom for scientific and clinical uses has restricted, up to now, the knowledge about the biochemistry, immunology, and pharmacology of these venoms. For this study, S. invicta venom was obtained commercially and used for proteomic characterization. For this purpose, the combination of gel-based and gel-free proteomic strategies was used to assign the proteomic profile of the venom from the fire ant S. invicta. This experimental approach permitted the identification of 46 proteins, which were organized into four different groups according to their potential role in fire ant venom: true venom components, housekeeping proteins, body muscle proteins, and proteins involved in chemical communication. The active venom components that may not present toxic roles were classified into three subgroups according to their potential functions: self-venom protection, colony asepsis, and chemical communication. Meanwhile, the proteins classified as true toxins, based on their functions after being injected into the victims' bodies by the fire ants, were classified in five other subgroups: proteins influencing the homeostasis of the victims, neurotoxins, proteins that promote venom diffusion, proteins that cause tissue damage/inflammation, and allergens. (AU) | |
| FAPESP's process: | 11/51684-1 - System biology as experimental strategy for discovery of novel natural products in the fauna of venomous arthropods from São Paulo State |
| Grantee: | Mario Sergio Palma |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 06/02115-6 - Survey of Solenopsis saevissima (Hymenoptera: Formicidae) venom biochemical components |
| Grantee: | Eduardo Gonçalves Paterson Fox |
| Support Opportunities: | Scholarships in Brazil - Doctorate |