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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardiovascular Disease in Early Kidney Transplantation: Comparison Between Living and Deceased Donor Recipients

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Author(s):
Yazbek, D. C. [1] ; de Carvalho, A. B. [1] ; Barros, C. S. [1] ; Marcassi, A. P. [1] ; Pestana, J. O. M. [1] ; Fachini, F. C. [2] ; Cassiolato, J. L. [3] ; Canziani, M. E. F. [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Div Nephrol, Sao Paulo - Brazil
[2] CDB, Sao Paulo - Brazil
[3] Cardios Res Inst, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Transplantation Proceedings; v. 44, n. 10, p. 3001-3006, DEC 2012.
Web of Science Citations: 9
Abstract

Background. Cardiovascular disease (CVD) mortality is extremely high among kidney transplant recipients (KTRs), particularly in the first months after transplantation. Few data are available comparing the cardiovascular profile between KTRs from living versus deceased donors. Objectives and methods. The aim of the present study was to evaluate the prevalence of CVD in the first 2 months following transplantation, among 120 KTRs of living versus deceased donor organs. Results. Left ventricular hypertrophy was observed in 65% of patients, coronary artery calcification in 30%, and cardiac arrhythmias in 46%. CVD was more prevalent among KTRs from deceased versus living donors: ventricular hypertrophy 87% versus 59% (P = .008); coronary artery calcification 42% versus 24% (P = .04); and cardiac arrhythmias 59% versus 39% (P = .06). Multiple logistic regression analysis adjusted for age and dialysis vintage, showed graft donor to not be associated with the prevalence of any CVD (beta coefficient 0.912, 95% confidence interval 0.276-3.012, P = .88). Conclusion. In conclusion, the present study demonstrated an elevated prevalence of CVD among KTRs. Patient characteristics, mainly longer length on dialysis seemed to contribute to a greater prevalence of cardiovascular complications among KTRs from deceased compared with living donors on univariate but not multivariate analysis. (AU)

FAPESP's process: 08/01420-5 - Effects of statins on cardiovascular disease progression in renal transplant recipients
Grantee:Maria Eugênia Fernandes Canziani
Support Opportunities: Regular Research Grants