| Full text | |
| Author(s): |
Orosz, Jose Eduardo B.
[1]
;
Braz, Mariana G.
[1]
;
Golim, Marjorie A.
[2]
;
Barreira, Marcio Antonio A.
[1]
;
Fecchio, Denise
[1]
;
Braz, Leandro G.
[1]
;
Braz, Jose Reinaldo C.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Estadual Paulista, UNESP, Botucatu Med Sch, Dept Anesthesiol, BR-18618970 Botucatu, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Botucatu Med Sch, Ctr Blood, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Inflammation; v. 35, n. 6, p. 1807-1813, DEC 2012. |
| Web of Science Citations: | 8 |
| Abstract | |
Patients undergoing surgical procedure develop an inflammatory response due to surgical trauma that may be modulated by anesthetics. The aim of this study was to investigate the cytokine profile in the plasma of adult patients who underwent minimally invasive surgery with balanced anesthesia with propofol, fentanyl, and sevoflurane. The study included 15 healthy patients scheduled for tympanoplasty or septoplasty under balanced anesthesia. Blood samples were drawn at four time points: before anesthesia, before surgery, 120 min after anesthesia induction, and on the first postoperative day. Plasma interleukin (IL)-1 beta, -2, -4, -6, -8, -10, -12, TNF-alpha, and INF-gamma levels were assessed by flow cytometry. IL-6 levels were elevated on the day after the surgery (p < 0.001). All other cytokines did not change either during or after balanced anesthesia (p > 0.05). In conclusion, balanced anesthesia with propofol, fentanyl, and sevoflurane anesthesia is not associated with intraoperative changes in the plasma cytokines in healthy patients undergoing minimally invasive otorhinological surgeries. Considering IL-6 results, a postoperative inflammatory response may have occurred due to surgical stress. (AU) | |
| FAPESP's process: | 09/51110-5 - Evaluation of oxidative DNA damage in lymphocytes, oxidative stress and cytokines profile in plasma from patients submitted to surgery and inhalational anesthesia with sevoflurane |
| Grantee: | Jose Reinaldo Cerqueira Braz |
| Support Opportunities: | Regular Research Grants |