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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lack of beta(2)-AR improves exercise capacity and skeletal muscle oxidative phenotype in mice

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Author(s):
Voltarelli, V. A. ; Bacurau, A. V. N. ; Bechara, L. R. G. ; Bueno Junior, C. R. [1] ; Bozi, L. H. M. ; Mattos, K. C. ; Salemi, V. M. C. [2] ; Brum, P. C. [3]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Human Genome Res Ctr, Biosci Inst, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Cardiomyopathy Unit, Heart Inst InCor, Sch Med, BR-05508900 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Biodinam Movimento Corpo Humano, Escola Educ Fis & Esporte, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS; v. 22, n. 6, p. e125-e132, DEC 2012.
Web of Science Citations: 5
Abstract

beta(2)-adrenergic receptor (beta(2)-AR) agonists have been used as ergogenics by athletes involved in training for strength and power in order to increase the muscle mass. Even though anabolic effects of beta(2)-AR activation are highly recognized, less is known about the impact of beta(2)-AR in endurance capacity. We presently used mice lacking beta(2)-AR {[}beta(2)-knockout (beta(2) KO)] to investigate the role of beta(2)-AR on exercise capacity and skeletal muscle metabolism and phenotype. beta(2) KO mice and their wild-type controls (WT) were studied. Exercise tolerance, skeletal muscle fiber typing, capillary-to-fiber ratio, citrate synthase activity and glycogen content were evaluated. When compared with WT, beta 2KO mice displayed increased exercise capacity (61%) associated with higher percentage of oxidative fibers (21% and 129% of increase in soleus and plantaris muscles, respectively) and capillarity (31% and 20% of increase in soleus and plantaris muscles, respectively). In addition, beta 2KO mice presented increased skeletal muscle citrate synthase activity (10%) and succinate dehydrogenase staining. Likewise, glycogen content (53%) and periodic acid-Schiff staining (glycogen staining) were also increased in beta 2KO skeletal muscle. Altogether, these data provide evidence that disruption of beta(2)AR improves oxidative metabolism in skeletal muscle of beta 2KO mice and this is associated with increased exercise capacity. (AU)

FAPESP's process: 08/56483-1 - Role of B2-adrenergic receptors in skeletal muscle disorders triggered by heart failure
Grantee:Vanessa Azevedo Voltarelli
Support type: Scholarships in Brazil - Master