Age-Related Maximum Heart Rate Among Ischemic and Nonischemic Heart Failure Patients Receiving beta-Blockade Therapy

Author(s)

Fernandes Silva, Miguel Morita ^{[1, 2]} ; Bacal, Fernando ^[1] ; Roque, Jean Marcelo ^{[1, 3]} ; Teixeira-Neto, Iram Soares ^{[1, 3]} ; Carvas Junior, Nelson ^[1] ; Bocchi, Edimar Alcides ^[1] ; Guimaraes, Guilherme Veiga ^{[1, 3]}

Affiliation

^[1] Univ Sao Paulo, Hosp Clin, Fac Med, Inst Heart, Sao Paulo - Brazil

^[2] Hosp Cardiol Costantini, Curitiba, Parana - Brazil

^[3] Univ Sao Paulo, Ctr Prat Esport, Lab Phys Act & Hlth, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF CARDIAC FAILURE; v. 18, n. 11, p. 831-836, NOV 2012.
• Web of Science Citations: 2

Abstract

Background: Equations to predict maximum heart rate (HRmax) in heart failure (HF) patients receiving beta-adrenergic blocking (BB) agents do not consider the cause of HF. We determined equations to predict HRmax in patients with ischemic and nonischemic HF receiving BB therapy. Methods and Results: Using treadmill cardiopulmonary exercise testing, we studied HF patients receiving BB therapy being considered for transplantation from 1999 to 2010. Exclusions were pacemaker and/or implantable defibrillator, left ventricle ejection fraction (LVEF) >50%, peak respiratory exchange ratio (RER) <1.00, and Chagas disease. We used linear regression equations to predict HRmax based on age in ischemic and nonischemic patients. We analyzed 278 patients, aged 47 +/- 10 years, with ischemic (n = 75) and nonischemic (n = 203) HF. LVEF was 30.8 +/- 9.4% and 28.6 +/- 8.2% (P = .04), peak VO2 16.9 +/- 4.7 and 16.9 +/- 5.2 mL kg(-1) min(-1) (P = NS), and the HRmax 130.8 +/- 23.3 and 125.3 +/- 25.3 beats/min (P = .051) in ischemic and nonischemic patients, respectively. We devised the equation HRmax = 168 - 0.76 x age (R-2 = 0.095; P = .007) for ischemic HF patients, but there was no significant relationship between age and HRmax in nonischemic HF patients (R-2 = 0.006; P = NS). Conclusions: Our study suggests that equations to estimate HRmax should consider the cause of HF. (J Cardiac Fail 2012;18:831-836) (AU)

• FAPESP's process: 06/03910-4 - Effect of the exercise training on breathing pattern evaluated by chemorreflexes and ergoreflexes in heart failure patients
• Grantee: Guilherme Veiga Guimarães
• Support Opportunities: Regular Research Grants