| Full text | |
| Author(s): Show less - |
Guethe, L. M.
[1, 2]
;
Pelegrini-da-Silva, A.
[3]
;
Borelli, K. G.
[2, 4]
;
Juliano, M. A.
[5]
;
Pelosi, G. G.
[3, 6]
;
Pesquero, J. B.
[5]
;
Silva, C. L. M.
[7]
;
Correa, F. M. A.
[3]
;
Murad, F.
[8]
;
Prado, W. A.
[3]
;
Martins, A. R.
[3, 2]
Total Authors: 11
|
| Affiliation: | [1] FFCLRP Univ Sao Paulo, Dept Psychol, BR-14049901 Ribeirao Preto - Brazil
[2] Univ Fed Triangulo Mineiro, Inst Biol Sci, BR-38025015 Uberaba, MG - Brazil
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Inst Neurosci & Behav INeC, BR-14049901 Ribeirao Preto, SP - Brazil
[5] Escola Paulista Med UNIFESP, Dept Biophys, BR-04044020 Sao Paulo - Brazil
[6] Univ Estadual Londrina, Dept Physiol Sci, Ctr Biol Sci, BR-86055900 Londrina, PR - Brazil
[7] Univ Fed Rio de Janeiro, ICB, Cellular & Mol Pharmacol Res Program, BR-21941599 Rio De Janeiro, RJ - Brazil
[8] George Washington Univ, Dept Biochem & Mol Biol, Washington, DC 20037 - USA
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Neuroscience; v. 231, p. 315-327, FEB 12 2013. |
| Web of Science Citations: | 6 |
| Abstract | |
Angiotensins (Angs) modulate blood pressure, hydro-electrolyte composition, and antinociception. Although Ang (5-8) has generally been considered to be inactive, we show here that Ang (5-8) was the smallest Ang to elicit dose-dependent responses and receptor-mediated antinociception in the rat ventrolateral periaqueductal gray matter (vlPAG). Ang (5-8) antinociception seems to be selective, because it did not alter blood pressure or act on vascular or intestinal smooth muscle cells. The non-selective Ang-receptor (Ang-R) antagonist saralasin blocked Ang (5-8) antinociception, but selective antagonists of Ang-R types I, II, IV, and Mas did not, suggesting that Ang (5-8) may act via an unknown receptor. Endopeptidase EP 24.11 and amastatin-sensitive aminopeptidase from the vlPAG catalyzed the synthesis (from Ang II or Ang III) and inactivation of Ang (5-8), respectively. Selective inhibitors of neuronal-nitric oxide (NO) synthase, soluble guanylyl cyclase (sGC) and a nonselective opioid receptor (opioid-R) inhibitor blocked Ang (5-8)-induced antinociception. In conclusion, Ang (5-8) is a new member of the Ang family that selectively and strongly modulates antinociception via NO-sGC and endogenous opioid in the vlPAG. (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 08/06676-8 - Cellular and molecular biology of the kallikrein-kinin and renin-angiotensin systems |
| Grantee: | João Bosco Pesquero |
| Support Opportunities: | Research Projects - Thematic Grants |