| Full text | |
| Author(s): |
Ebersbach-Silva, Patricia
[1]
;
Alves, Thamara
[1]
;
Sakata Fonseca, Agatha Tomoko
[1]
;
do Nascimento Oliveira, Marcia Aparecida
[2]
;
Machado, Ubiratan Fabres
[2]
;
Seraphim, Patricia Monteiro
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Estadual Paulista, Dept Phys Therapy, Sch Sci & Technol, UNESP, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Arquivos Brasileiros de Endocrinologia e Metabologia; v. 57, n. 1, p. 19-26, FEB 2013. |
| Web of Science Citations: | 4 |
| Abstract | |
OBJECTIVE: To evaluate the effect of exposure to cigarette smoke and running training on a treadmill on the expression of glucose transporter GLUT4 in oxidative soleus muscle of rats. MATERIALS AND METHODS: Wistar rats were divided into: (C) control, (E) exercise control, (SS), sedentary smoker, and (ES) exercise smoker. Insulin Tolerance Test, Western blotting, and RT-PCR were performed for the evaluation of GLUT4 levels. RESULTS: The SS group presented lower insulin sensitivity with reduced GLUT4 protein in the plasma membrane (PM), no changes in the microsomal fraction, but increased mRNA content. Training reversed this condition. No intervention altered total GLUT4 content of the oxidative muscle. CONCLUSION: These results suggest that passive smoking stimulates GLUT4 transcription without changing total protein content, but impairs the ability of GLUT4 translocation to the PM. On the other hand, training seems to reduce the deleterious effects, even under the influence of cigarette smoking. (AU) | |
| FAPESP's process: | 08/10886-8 - GLUT4 and SOCS-3 expression in skeletal muscle from smokers rats submitted to moderated aerobic exercise |
| Grantee: | Thâmara Alves |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 04/10130-0 - Avaliação da expressão de proteínas transportadoras de glicose (gluts) central e perifericamente em ratos resistentes à insulina |
| Grantee: | Patricia Monteiro Seraphim |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 08/09328-0 - GLUT4 glucose transporter expression evaluation in skeletal muscle soleum from sedentary and exercited passive smokers rats |
| Grantee: | Ágatha Tomoko Sakata Fonseca |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 08/01955-6 - Effect of passive tobaccoism and physical exercise-associated on glucose transporter GLUT4 expression in muscles of rats |
| Grantee: | Patrícia Ebersbach Silva |
| Support Opportunities: | Scholarships in Brazil - Master |