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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of Antimicrobial Photodynamic Therapy on Transforming Growth Factor-beta 1 Levels in the Gingival Crevicular Fluid

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Author(s):
Souza, Sergio L. S. [1] ; Andrade, Patricia F. [1] ; Silva, Joao S. [2] ; Tristao, Fabrine S. M. [2] ; Rocha, Fernanda A. [2] ; Palioto, Daniela B. [1] ; Grisi, Marcio F. M. [1] ; Taba, Jr., Mario [1] ; Novaes, Jr., Arthur B. [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Dept Buccomaxillofacial Surg & Traumatol & Period, Sch Dent Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Immunol, Sch Med Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Photomedicine and Laser Surgery; v. 31, n. 2, p. 65-71, FEB 2013.
Web of Science Citations: 6
Abstract

Background and objective: Antimicrobial photodynamic therapy (aPDT) has been proposed as an adjunctive therapy to scaling and root planing (SRP). The transforming growth factor-beta 1 (TGF-beta) has been considered as an anti-inflammatory cytokine, and its levels in the gingival crevicular fluid (GCF) could monitor the periodontal repair. This study evaluated the adjunct effect of aPDT compared with SRP, analyzing the TGF-beta levels in GCF after nonsurgical and surgical therapy in chronic periodontitis patients. Methods: Fifteen patients, presenting bilaterally lower molars with class III furcation lesions, were selected. Each pair of teeth was randomly assigned to a control group (CG) or test group (TG). Initially, SRP was performed in the CG, and SRP + aPDT in the TG. Forty-five days later, flap surgery plus SRP, and flap surgery plus SRP + aPDT were performed in CG and TG, respectively. GCF was collected and an enzyme-linked immunosorbent assay (ELISA) test was conducted to determine the amount and concentration of TGF-beta in the GCF at baseline, 45 days post-initial therapy, and 21 days after surgery. Results: Statistically significant differences between groups were found in relation to GCF volume 21 days after the surgical procedures (p = 0.03) and TGF-beta concentration in GCF 45 days post-initial therapy (p = 0.04), favoring the TG. Conclusions: There was an additional effect of the aPDT protocol compared with SRP for the TGF-beta concentration in GCF 45 days after nonsurgical therapy, and for the GCF volume 21 days after surgical therapy. (AU)

FAPESP's process: 07/04916-9 - Evaluation of the photodynamic therapy on root decontamination and modulation of the immuno-inflammatory response and healing of the periodontal tissues: a randomized controlled clinical study in humans
Grantee:Sérgio Luís Scombatti de Souza
Support Opportunities: Regular Research Grants