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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

High levels of Cellular Prion Protein improve astrocyte development

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Author(s):
Hartmann, Camila Arantes [1, 2] ; Martins, Vilma Regina [2] ; Souza Lima, Flavia Regina [2, 3]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo - Brazil
[2] AC Camargo Hosp, Int Res Ctr, Sao Paulo - Brazil
[3] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Ctr Ciencias Saude, BR-21941902 Rio De Janeiro - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FEBS Letters; v. 587, n. 2, p. 238-244, JAN 16 2013.
Web of Science Citations: 10
Abstract

Prion protein (PrPC) has neuroprotective functions and herein we demonstrate that astrocytes from PrPC-over-expressing mice are more resistant to induced cell death than wild-type astrocytes. The Stress-Inducible-Protein 1 (STI1), a PrPC ligand, prevents cell death in both wild-type and PrPC-over-expressing astrocytes through the activation of protein-kinase-A. Cultured embryonic astrocytes and brain extracts from PrPC-over-expressing mice show higher glial fibrillary acidic protein expression and reduced vimentin and nestin levels when compared to wild-type astrocytes, suggesting faster astrocyte maturation in the former mice. Our data indicate that PrPC levels modulate astrocyte development, and that PrPC-STI1 interaction contributes to protect against astrocyte death. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. (AU)

FAPESP's process: 09/14027-2 - Mechanisms associated with the function of prion protein and its ligand STI1/Hop: therapeutic approaches
Grantee:Vilma Regina Martins
Support type: Research Projects - Thematic Grants