Evaluation of Different Media for the Production of Cephalosporins by Streptomyces clavuligerus ATCC 27064

Author(s)

Antonio, Tatiana ^[1] ; Bellao, Carolina ^[2] ; Correa, Tatiana ^[1] ; Cavallieri, Andre Pastrelo ^[1] ; Badino, Alberto Colli ^[2] ; Gonsales da Costa Araujo, Maria Lucia ^[1]

Affiliation

^[1] Univ Estadual Paulista, Dept Bioquim & Quim Tecnol, Inst Quim, BR-14800900 Araraquara, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Engn Quim, BR-13565905 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Brazilian Archives of Biology and Technology; v. 55, n. 6, p. 819-825, NOV-DEC 2012.
• Web of Science Citations: 4

Abstract

The aim of this work was to compare the composition of a complex and soluble culture medium to eight other media described in the literature through the batch cultivation in a conventional bench-scale bioreactor for the production of cephamycin C by a wild strain of Streptomyces clavuligerus. The proposed medium resulted in an antibiotic production 1.5 to 7.5 times higher than the other culture media. (AU)

• FAPESP's process: 08/03579-1 - Screening of induced mutants in Streptomyces clavuligerus and culture medium optimization for enhancement of cephamycin C production
• Grantee: Tatiana Antonio
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 05/55079-4 - Production and purification of clavulanic acid, cephamycin C and other bioactive metabolites of Streptomyces
• Grantee: Carlos Osamu Hokka
• Support Opportunities: Research Projects - Thematic Grants