Non-Hodgkin lymphoma in adults: protein profile of cerebrospinal fluid and serum in 25 patients

Author(s)

SYLVIA REGINA MIELLI ^[1] ; BEATRIZ BEITLER ^[2] ; CLÁUDIO GALPERIN ^[3] ; VIVIANA B. PALOU ^[4] ; JOSÉ ANTONIO LIVRAMENTO ^[5] ; LUÍS DOS RAMOS MACHADO ^[6] ; HÉLIO RODRIGUES GOMES ^[7]

Affiliation

^[1] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[2] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[3] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[4] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[5] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[6] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[7] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

• Document type: Journal article
• Source: Arquivos de Neuro-Psiquiatria; v. 56, n. 4, p. 769-771, 1998-12-00.

Abstract

Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were colleted in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an incidence of neurologic signs and symptoms in 48% of all patients. Samples analysis showed: increase of total protein in CSF in 52%; local synthesis of IgG in one HIV seropositive patient; IgG concentration increase in the CSF in the absense of malignant cells in the CSF in two patients that clinically improved after chemotherapy; oligoclonal bands only in the CSF in one HTLV-I seropositive patient. These data show that the study of CSF protein profile can contribute in the characterization of CNS involvement in non-Hodgkin lymphoma. (AU)