Interaction between humic substances and metallic ions: a selectivity study of humic substances and their possible therapeutic application

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Author(s):	Ademir dos Santos ^[1] ; Wander Gustavo Botero ^[2] ; Iramaia Corrêa Bellin ^[3] ; Luciana Camargo de Oliveira ^[4] ; Julio Cesar Rocha ^[5] ; André Gustavo Ribeiro Mendonça ^[6] ; Antonio Francisco Godinho ^[7] Total Authors: 7
Affiliation:	^[1] Universidade Estadual de São Paulo. Instituto de Química - Brasil ^[2] Universidade Estadual de São Paulo. Instituto de Química - Brasil ^[3] Universidade Estadual de São Paulo. Instituto de Química - Brasil ^[4] Universidade Estadual de São Paulo. Instituto de Química - Brasil ^[5] Universidade Estadual de São Paulo. Instituto de Química - Brasil ^[6] Universidade Estadual de São Paulo. Instituto de Química - Brasil ^[7] Universidade Estadual de São Paulo. Instituto de Biociências. Centro de Assistência Toxicológica - Brasil Total Affiliations: 7
Document type:	Journal article
Source:	Journal of the Brazilian Chemical Society; v. 18, n. 4, p. 824-830, 2007-00-00.
Abstract
The complexation capacity of humic substances extracted from peat samples taken from the Mogi River in Ribeirao Preto, SP, Brazil, was determined using metal ions (Al(III), Pb(II), Cr(VI) and Cd(II)), yielding the following order of affinity: Cr(VI)< Cd(II)<Pb(II)<Al(III). An oral LD50 test showed that these humic substances are nontoxic up to a maximum concentration of 512 mg kg-1. These findings reinforce the possibility of using humic substances as a metal detoxicant. (AU)