Acute aerocystitis in Piaractus mesopotamicus: Participation of eicosanoids and pro-inflammatory cytokines

Author(s)

Claudiano, Gustavo da Silva ^[1] ; Petrillo, Thalita R. ^[1] ; Manrique, Wilson G. ^[1] ; Castro, Marcello P. ^[1] ; Loureiro, Bruna A. ^[1] ; Marcusso, Paulo F. ^[1] ; Belo, Marco A. A. ^[1] ; Moraes, Julieta R. E. ^[1] ; de Moraes, Flavio Ruas ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Agrarian & Vet Sci, Dept Vet Pathol, BR-14884900 Jaboticabal, SP - Brazil

• Document type: Journal article
• Source: FISH & SHELLFISH IMMUNOLOGY; v. 34, n. 5, p. 1057-1062, MAY 2013.
• Web of Science Citations: 13

Abstract

A total of 360 pacus (Piaractus mesopotamicus) were used to study vascular permeability (VP) and inflammatory cell component (CC) in induced aerocystitis in P. mesopotamicus through inoculation of inactivated Aeromonas hydrophila, and the effect of steroidal and nonsteroidal anti-inflammatory drugs. It was observed that after inoculation of A. hydrophila, the maximum VP occurred 180 min post-stimulus (MPS). Pretreatment with anti-inflammatory drugs inhibited VP, and the inhibitory effect of dexamethasone was seen earlier than the effects caused by meloxicam and indomethacin. Inoculation of the bacterium caused a gradual increase in the accumulation of cells, which reached a maximum 24 h post-stimulus (HPS). Pretreatment with dexamethasone, indomethacin and meloxicam reduced the accumulation of lymphocytes, thrombocytes, granulocytes and macrophages. There was no significant difference between the different doses of the drugs tested. The results suggest that eicosanoids and pro-inflammatory cytokines participate in chemical mediation in acute inflammation in pacus. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 09/16178-8 - Effect of drugs steroid anti-inflammatory and non-steroidal in acute inflammation induced Piaractus Aeromonas hydrophila
• Grantee: Flávio Ruas de Moraes
• Support Opportunities: Regular Research Grants