| Full text | |
| Author(s): |
Panzan, Michele Q.
[1]
;
Mattar, Rosiane
[2]
;
Maganhin, Carla C.
[1]
;
Simoes, Ricardo dos Santos
[3]
;
Zabeu Rossi, Alexandre Guilherme
[1]
;
Alves da Motta, Eduardo Leme
[1]
;
Baracat, Edmund C.
[3]
;
Soares-, Jr., Jose Maria
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Gynaecol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Obstet, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Obstet & Gynaecol, Gynaecol Div, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY; v. 167, n. 1, p. 47-52, MAR 2013. |
| Web of Science Citations: | 16 |
| Abstract | |
Objective: To investigate expression of BcL-2, FAS, FAS ligand (FASL) and cleaved caspase-3 in the endometrial tissue of women with idiopathic infertility (with two consecutive failed cycles of in vitro fertilization) and women with idiopathic recurrent pregnancy loss. The control group consisted of fertile women. Study design: Endometrial tissue samples from fertile women (n = 25), women with idiopathic infertility (n = 25) and women with idiopathic recurrent pregnancy loss (n = 25) were collected on the seventh or eighth postovulatory day of their menstrual cycles for evaluation. Expression of BcL-2, FAS, FASL and cleaved caspase-3 was assessed using immunohistochemical methods. Results: Expression of BcL-2 and FAS was significantly higher and lower, respectively, in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of cleaved caspase-3 was significantly lower in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of FASL was similar in all three groups. Conclusion: Disturbances in endometrial apoptosis may be a contributing factor in patients with idiopathic infertility and recurrent pregnancy loss. (C) 2012 Elsevier Ireland Ltd. All rights reserved. (AU) | |