| Full text | |
| Author(s): |
Altemani, Albina
[1]
;
Costa, Ana Flavia
[1]
;
Montalli, Victor Angelo M.
[1]
;
Mosqueda-Taylor, Adalberto
[2]
;
de Almeida, Oslei Paes
[3]
;
Leon, Jorge E.
[4]
;
Hermsen, Mario
[5]
Total Authors: 7
|
| Affiliation: | [1] Univ Campinas UNICAMP, Dept Pathol, Campinas, SP - Brazil
[2] Univ Autonoma Metropolitana Xochimilco, Dept Hlth Care, Mexico City, DF - Mexico
[3] Univ Campinas FOP UNICAMP, Dept Oral Pathol, Piracicaba, SP - Brazil
[4] Univ Sao Paulo FORP USP, Dept Oral Pathol, Ribeirao Preto, SP - Brazil
[5] Hosp Univ Cent Asturias, Dept Otolaryngol, IUOPA, Oviedo - Spain
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Histopathology; v. 62, n. 4, p. 531-542, MAR 2013. |
| Web of Science Citations: | 4 |
| Abstract | |
Aims Signet-ring cell (SRC) change has not been reported in adenoid cystic carcinoma (ACC). The aim of this study was to describe the clinicopathological and immunohistochemical findings in four cases of ACC with SRCs (ACC-SRC), in which the relative proportion of the SRC component ranged from 25% to 50%. Methods and results The median age was 58years (range: 4881years), and all patients were women. The involved sites were sinonasal, lip, and submandibular. Two patients developed lung metastasis, and one died of disease 63months after tumour resection. Neither mucinous nor lipid substances were detected in the SRCs. These showed positive staining for AE1/AE3, cytokeratin 14, and epithelial membrane antigen, which highlighted the intracytoplasmic vacuole borders. The SRC nests were surrounded by myoepithelial cells positive for -smooth muscle actin and p63. The SRCs showed similar p53 positivity but lower Ki67 and mitotic indices than the conventional component. SRCs were c-Myb-negative. Ultrastructural examination revealed that the intracytoplasmic vacuoles were lumina lined by microvilli. Conclusions ACC-SRC is a non-mucin-producing and non-lipid-producing phenomenon, possibly related to disturbed differentiation of ductal/luminal cells. This cellular modification in ACC apparently does not change the biological behaviour of the tumour, but it may cause significant diagnostic problems, particularly in incisional biopsies. (AU) | |
| FAPESP's process: | 10/51571-0 - Identification of genetic and epigenetic alterations in adenoid cystic carcinoma with high-grade transformation |
| Grantee: | Albina Messias de Almeida Milani Altemani |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/54377-2 - Identification of genetic and epigenetic alterations in adenoid cystic carcinoma with high-grade transformation |
| Grantee: | Ana Flávia de Mattos Costa |
| Support Opportunities: | Scholarships in Brazil - Doctorate |