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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

3D element imaging using NSECT for the detection of renal cancer: a simulation study in MCNP

Full text
Author(s):
Viana, R. S. [1, 2] ; Agasthya, G. A. [2, 3] ; Yoriyaz, H. [1] ; Kapadia, A. J. [2, 4]
Total Authors: 4
Affiliation:
[1] IPEN CEN SP, Inst Nucl Energy Res, Nucl Engn Ctr, Sao Paulo - Brazil
[2] Duke Univ, Dept Radiol, Carl E Ravin Adv Imaging Labs, Durham, NC 27710 - USA
[3] Duke Univ, Dept Biomed Engn, Durham, NC 27706 - USA
[4] Duke Univ, Med Phys Grad Program, Durham, NC 27710 - USA
Total Affiliations: 4
Document type: Journal article
Source: Physics in Medicine and Biology; v. 58, n. 17, p. 5867-5883, SEP 7 2013.
Web of Science Citations: 3
Abstract

This work describes a simulation study investigating the application of neutron stimulated emission computed tomography (NSECT) for noninvasive 3D imaging of renal cancer in vivo. Using MCNP5 simulations, we describe a method of diagnosing renal cancer in the body by mapping the 3D distribution of elements present in tumors using the NSECT technique. A human phantom containing the kidneys and other major organs was modeled in MCNP5. The element composition of each organ was based on values reported in literature. The two kidneys were modeled to contain elements reported in renal cell carcinoma (RCC) and healthy kidney tissue. Simulated NSECT scans were executed to determine the 3D element distribution of the phantom body. Elements specific to RCC and healthy kidney tissue were then analyzed to identify the locations of the diseased and healthy kidneys and generate tomographic images of the tumor. The extent of the RCC lesion inside the kidney was determined using 3D volume rendering. A similar procedure was used to generate images of each individual organ in the body. Six isotopes were studied in this work-S-32, C-12, Na-23, N-14, P-31 and K-39. The results demonstrated that through a single NSECT scan performed in vivo, it is possible to identify the location of the kidneys and other organs within the body, determine the extent of the tumor within the organ, and to quantify the differences between cancer and healthy tissue-related isotopes with p <= 0.05. All of the images demonstrated appropriate concentration changes between the organs, with some discrepancy observed in P-31, K-39 and Na-23. The discrepancies were likely due to the low concentration of the elements in the tissue that were below the current detection sensitivity of the NSECT technique. (AU)

FAPESP's process: 10/04206-4 - Spectrometry and reconstruction of neutron stimulated emission computed tomography images via the EM algorithm and Monte Carlo Method
Grantee:Rodrigo Sartorelo Salemi Viana
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/01564-2 - Emission tomography stimulated by neutrons: experiments for validation and Monte Carlo simulations
Grantee:Rodrigo Sartorelo Salemi Viana
Support Opportunities: Scholarships abroad - Research Internship - Doctorate