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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Expression of HOXC9 and E2F2 are up-regulated in CD133+ cells isolated from human astrocytomas and associate with transformation of human astrocytes

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Author(s):
Okamoto, Oswaldo K. [1] ; Oba-Shinjo, Sueli M. ; Lopes, Luciana ; Marie, Suely K. Nagahashi [4]
Total Authors: 4
Affiliation:
[1] Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) - Brasil
[4] Universidade de São Paulo (USP). Faculdade de Medicina. Departamento de Neurologia - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Biochimica et Biophysica Acta (BBA) : Gene Structure and Expression; v. 1769, n. 7/8, p. 437-442, July 2007.
Field of knowledge: Health Sciences - Medicine
Abstract

Comparative analysis of cancer stem cells with their neoplastic and non-neoplastic counterparts should help better understand the underlying molecular events leading to transformation and tumor dissemination. Here, we report a molecular signature comprised by genes with exclusive aberrant expression in CD133+ cells, a reported subpopulation of tumorigenic stem-like cells, isolated from human glioblastomas. Microarrays covering 55,000 transcripts were used to compare gene expression profiles in purified subpopulations of CD133+ and CD133- GBM cells. Sixteen genes, many of which not previously associated with astrocytomas, were found aberrantly expressed in CD133+ cells, but not in CD133-, when compared with corresponding non-neoplastic controls. Up-regulation of two of such genes, E2F2 and HOXC9, was detected in a set of 54 astrocytomas of different grades and significantly associated with malignancy. Due to their distinctive expression in CD133+ cells, the use of E2F2 and HOXC9 as therapeutic targets for tumor eradication is suggested. (AU)