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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning

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Author(s):
Alves, Fernando H. F. [1] ; Gomes, Felipe V. [1, 2] ; Reis, Daniel G. [1] ; Crestani, Carlos C. [3] ; Correa, Fernando M. A. [1] ; Guimaraes, Francisco S. [1, 2] ; Resstel, Leonardo B. M. [1, 2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-14049900 Sao Paulo - Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: European Journal of Neuroscience; v. 38, n. 2, p. 2300-2307, JUL 2013.
Web of Science Citations: 13
Abstract

The insular cortex (IC) has been reported to be involved in the modulation of memory and autonomic and defensive responses. However, there is conflicting evidence about the role of the IC in fear conditioning. To explore the IC involvement in both behavioral and autonomic responses induced by contextual fear conditioning, we evaluated the effects of the reversible inhibition of the IC neurotransmission through bilateral microinjections of the non-selective synapse blocker CoCl2 (1mm) 10min before or immediately after the conditioning session or 10min before re-exposure to the aversive context. In the conditioning session, rats were exposed to a footshock chamber (context) and footshocks were used as the unconditioned stimulus. Forty-eight hours later, the animals were re-exposed to the aversive context for 10min, but no shock was given. Behavioral (freezing) as well as cardiovascular (arterial pressure and heart rate increases) responses induced by re-exposure to the aversive context were analysed. It was observed that the local IC neurotransmission inhibition attenuated freezing and the mean arterial pressure and heart rate increase of the groups that received the CoCl2 either immediately after conditioning or 10min before re-exposure to the aversive context, but not when the CoCl2 was injected before the conditioning session. These findings suggest the involvement of the IC in the consolidation and expression of contextual aversive memory. However, the IC does not seem to be essential for the acquisition of memory associated with aversive context. (AU)

FAPESP's process: 11/21921-1 - The participation of the medial prefrontal cortex in reconsolidation and extinction processes of the aversive conditioned memory: possible interaction between glutamate - nitric oxide pathway and the endocanabinoids
Grantee:Daniel Gustavo dos Reis
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/07332-3 - Possible role of dorsal hippocampus on behaviour and autonomic responses during defensive responses: involvement of NMDA receptor/nitric oxide and endocanabinoid
Grantee:Leonardo Resstel Barbosa Moraes
Support type: Regular Research Grants
FAPESP's process: 10/09462-9 - Study of peripheral mechanisms involved in the cardiovascular response during sepsis in rats: possible involvement of the endocannabinoid system
Grantee:Fernando Henrique Ferrari Alves
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/09300-4 - Bed nucleus of the stria terminalis noradrenergic system modulates contextual fear conditionig: possible interaction with CRF and glutamatergic and nitrergic neurotransmission
Grantee:Leonardo Resstel Barbosa Moraes
Support type: Regular Research Grants