| Full text | |
| Author(s): |
Russo, Anelise
[1, 2]
;
Francelin, Pamela Risardi
[1, 2]
;
Silva Galbiatti, Ana Livia
[1, 2]
;
Raposo, Luis Sergio
[3]
;
Maniglia, Jose Victor
[3]
;
Pavarino, Erika Cristina
[1, 2]
;
Goloni-Bertollo, Eny Maria
[1, 2]
Total Authors: 7
|
| Affiliation: | [1] Sao Jose do Rio Preto Med Sch FAMERP, Fac Med Sao Jose do Rio Preto, Dept Mol Biol & Genet, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] Sao Jose do Rio Preto Med Sch FAMERP, Fac Med Sao Jose do Rio Preto, Mol Biol Res Unit UPGEM, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[3] Sao Jose do Rio Preto Med Sch FAMERP, Dept Otorhinolaryngol & Head & Neck Surg, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | MOLECULAR BIOLOGY REPORTS; v. 40, n. 7, p. 4181-4188, JUL 2013. |
| Web of Science Citations: | 6 |
| Abstract | |
Polymorphisms in the glutathione S-transferase superfamily genes that encodes enzymes involved in the phase II xenobiotic metabolism may lead head and neck cancer development. In this study we investigate the association of A313G and C341T GSTP1 polymorphisms, GSTM1 and GSTT1 null genotypes in the head and neck cancer development, interactions between these polymorphisms,the tumor histopathologic parameters and risk factors (smoking and drinking) were also evaluated in the case-control study. 775 individuals (261 patients/514 controls) were included in the study. Molecular analyzes were performed by PCR and PCR-RFLP; and statistical analyzes by Chi square and multiple logistic regression. Chi square test showed that only the genotype frequencies for GSTM1 and GSTT1 were in Hardy-Weinberg disequilibrium in both groups. Significant results with p a parts per thousand currency sign 0.05 showed that age a parts per thousand yen 48 years (OR = 11.87; 7.55-18.65), smoking (OR = 4.25; 2.70-6.69), drinking (OR = 1.59; 1.02-2.46) were possible predictors for the head and neck cancer development and the presence of A313G GSTP1 polymorphism (OR = 0.62; 0.42-0.92) decreased the risk for this disease. Individuals with the 313AG/GG GSTP1 and age a parts per thousand yen 48 years (OR = 0.59; 0.38-0.91), male gender (OR = 0.54; 0.35-0.83), smokers (OR = 0.63; 0.40-0.99) and drinkers (OR = 0.57; 0.35-0.95); the GSTM1 null genotype and age < 48 years (OR = 2.46; 1.09-5.55); the GSTT1 null genotype and primary anatomical sites of pharynx (OR = 0.37; 0.17-0.79) and larynx (OR = 3.60; 1.93-6.72), can modulate the risk for the disease development. The variables age a parts per thousand yen 48 years, smoking and drinking can be predictors for head and neck cancer development; moreover, A313G GSTP1 polymorphism, GSTM1 and GSTT1 null genotypes can modulate the risk for this disease. (AU) | |
| FAPESP's process: | 07/08155-2 - Gene polymorphisms of xenobiotic-metabolizing in patients with head and neck cancer. |
| Grantee: | Eny Maria Goloni Bertollo |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/05875-0 - Polymorphism of GSTP1 gene in head and neck cancer patients |
| Grantee: | Marianna Angelo Palmejani |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |