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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats

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Author(s):
Matos, Gabriela [1] ; Tenorio, Neuli M. [1] ; Bergamaschi, Cassia T. [2] ; Campos, Ruy R. [2] ; Cintra, Fatima [1] ; Tufik, Sergio [1] ; Andersen, Monica L. [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Fisiol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 44, p. 34-38, JUL 1 2013.
Web of Science Citations: 7
Abstract

Although the influence of sex on sleep pattern and cardiovascular parameters is well known, knowledge regarding the effects of sleep loss on heart responses in both sexes is scarce. The present study investigated the effects of paradoxical sleep deprivation (PSD) and chronic sleep restriction (SR) on cardiovascular parameters and adrenocorticotropic hormone (ACTH) levels in male and female rats. Both groups were randomly assigned to PSD for 96 h, SR for 21 days or home-cage control. Mean arterial pressure (MAP), heart rate (HR), baroreflex sensitivity (bradycardia and tachycardia responses) and ACTH levels were evaluated. The results showed that PSD induced a significant increase in HR and ACTH levels in both sexes, although male rats presented higher levels of ACTH hormone compared to females. In addition to sex-specific responses, PSD decreased the tachycardia only in male rats. SR, induced a significant increase in MAP and decrease in bradycardia in both sexes. Male rats were more affected by sleep deprivation protocols than females for MAP, bradycardia response, and ACTH levels. The results showed that the effects of sleep loss on cardiovascular parameters are associated with the protocol of sleep deprivation and that sex can modulate these effects. We suggested this experimental model as a suitable tool for further investigations of the relationship between cardiovascular parameters and sleep. (C) 2013 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 10/15110-8 - Sleep and sudden unexpected death in epilepsy: possible molecular basis?
Grantee:Gabriela de Matos Barbosa Pimenta
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/05396-7 - Consequences of sleep restriction during pregnancy on the development of sensory-motor and sexual behavior in the offspring
Grantee:Monica Levy Andersen
Support type: Regular Research Grants