Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Susceptibility to Mycobacterium tuberculosis Infection in HIV-Positive Patients Is Associated With CARD8 Genetic Variant

Full text
Author(s):
Pontillo, Alessandra [1] ; Carvalho, Marcia S. [2] ; Kamada, Anselmo J. [2] ; Moura, Ronald [2] ; Schindler, Haiana C. [3] ; Duarte, Alberto J. S. [1] ; Crovella, Sergio [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med, Lab Med Invest Dermatol & Immunodeficiency, LIM 56, BR-05403000 Sao Paulo - Brazil
[2] Univ Fed Pernambuco, Dept Genet, Recife, PE - Brazil
[3] Aggeu Magalhaes Res Ctr CPqAM FIOCRUZ, Dept Immunol, Recife, PE - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES; v. 63, n. 2, p. 147-151, JUN 1 2013.
Web of Science Citations: 17
Abstract

HLA and other genetic variants, playing an important role in innate and adaptive immunity, are known to influence tuberculosis (TB) development in HIV-1-positive (HIV+) patients. Because inflammasome genes contribute to HIV-1 susceptibility, we investigated the possible association between polymorphisms in inflammasome genes with HIV-1 and Mycobacterium tuberculosis coinfection (HIV+ TB+) in a case/control cohort of Brazilian individuals. Nineteen single-nucleotide polymoprhims in 8 inflammasome genes (NLRP1, NLRP3, AIM2, CARD8, CASP1, IL1B, IL1R, and HSP90) were analyzed in HIV+ TB+ Brazilian patients (from Recife, Pernambuco). CARD8 rs6509365 polymorphism was associated with HIV+ TB+ (P = 5 x 10(-5)), suggesting a predisposing role of this variant in M. tuberculosis susceptibility in HIV+ subjects (odds ratio = 2.45). This effect is even strong when this allele is combined to CARD8 rs2043211 single-nucleotide polymoprhim. The results of this study support the novel association between CARD8 gene and HIV+ TB+ coinfection, demonstrating that inflammasome genetics could influence HIV-1 infection and the development of opportunistic infection. (AU)

FAPESP's process: 09/53575-5 - Possible role of inflammasome in the immune response against virus HIV-1
Grantee:Alberto José da Silva Duarte
Support Opportunities: Regular Research Grants