| Full text | |
| Author(s): |
da Silva, Isis Tande
[1]
;
de Queiroz Mello, Ana Paula
[1]
;
Sanches, Leticia Bertoldi
[1]
;
Parra Abdalla, Dulcineia Saes
[2]
;
Teixeira Damasceno, Nagila Raquel
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin Anal & Biochem, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY; v. 59, n. 2, p. 100-107, APR 2013. |
| Web of Science Citations: | 2 |
| Abstract | |
Obesity has increased in children and adolescents. What is reflected in the early occurrence of cardiometabolic alterations, like hypertension and type 2 diabetes, where the oxLDL formation is stimulated. Various studies have shown that plasma alpha-tocopherol (alpha-TP) can protect LDL against oxidation. Nevertheless, the action of plasma alpha-TP in cardiovascular diseases remains controversial. We conducted a cross-sectional study to evaluate plasma alpha-TP and its impact on the concentration of LDL(-). Adolescents (n=150) of both sexes were classified into three groups: healthy weight (HW; 50%), overweight (OV; 22%), and obese (OB; 28%). Lipid profile, LDL(-), anti-oxLDL and anti-LDL(-) antibodies, CRP (ELISA) and plasma alpha-TP (HPLC) were analyzed. Demographic, anthropometric, and food intake data were evaluated. Crude and energy-adjusted intake of vitamin E in the OB group were higher than in the HW group (p<0.001). Crude and energy-adjusted vitamin E intakes were not correlated with plasma alpha-TP (r=-0.07; p=0.412 and r=-0.064; p=0.467, respectively). Subjects in the OB group had higher TC and LDL-C and lower LDL-C than in the HW and OV groups. C-reactive protein and anti-oxLDL antibodies changed as a function of BMI. The impact of obesity was reinforced by high values for LDL(-) and low content of plasma alpha-TP in comparison with the HW (p<0.001) and OV groups (p=0.03). This negative profile was maintained for the ratio between alpha-TP and TC or LDL-C. Plasma alpha-TP, alpha-TP/TC and alpha-TP/LDL-C were negatively associated with LDL(-) and other cardiometabolic risk factors (BMI WC, AC and anti-oxLDL). Our results demonstrate that obesity in adolescents is associated with high levels of LDL(-) and low plasma alpha-TP content. (AU) | |