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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polymorphism of the CYP1A1*2A gene and susceptibility to lung cancer in a Brazilian population

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Author(s):
Helen Naemi Honma [1] ; Eduardo Mello De Capitani [2] ; Aristóteles de Souza Barbeiro [3] ; Daniel Botelho Costa [4] ; André Morcillo [5] ; Lair Zambon [6]
Total Authors: 6
Affiliation:
[1] University at Campinas. School of Medical Sciences. Laboratory of Pulmonology/Oncology - Brasil
[2] University at Campinas. School of Medical Sciences. Department of Clinical Medicine - Brasil
[3] University at Campinas. School of Medical Sciences. Hospital das Clínicas - Brasil
[4] Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Hematology/Oncology - Estados Unidos
[5] University at Campinas. School of Medical Sciences. Department of Pediatrics - Brasil
[6] University at Campinas. School of Medical Sciences. Department of Clinical Medicine - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Jornal Brasileiro de Pneumologia; v. 35, n. 8, p. 767-772, 2009-08-00.
Field of knowledge: Biological Sciences - Genetics
Abstract

OBJECTIVE: To estimate and compare the frequency of CYP1A1*2A gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to lung cancer risk. METHODS: The study population included 200 patients with lung cancer, and the control group consisted of 264 blood donors. Genomic DNA was obtained from peripheral blood samples. The PCR-RFLP method was used for analysis of the CYP1A1*2A gene. RESULTS: There was no statistically significant difference between the lung cancer patients and the controls in terms of the distribution of CYP1A1*2A polymorphisms (p = 0.49). A multivariate logistic regression model analysis by ethnic group revealed that, within the lung cancer group, the CYP1A1*2A genotype CC plus TC was more common among the African-Brazilian patients than among the White patients (adjusted OR = 3.19; 95% CI: 1.53-6.65). CONCLUSIONS: The CYP1A1*2A gene cannot be linked with lung cancer risk in Brazilian patients at this time. Larger epidemiologic studies are needed in order to establish whether the CC plus TC polymorphism increases the risk of lung cancer in African-Brazilians. (AU)