Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans

Author(s)

Perry, Juliana C. ^[1] ; Guindalini, Camila ^[1] ; Bittencourt, Lia ^[1] ; Garbuio, Silverio ^[1] ; Mazzotti, Diego R. ^[1] ; Tufik, Sergio ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil

• Document type: Journal article
• Source: Respiratory Physiology & Neurobiology; v. 189, n. 3, p. 649-654, DEC 1 2013.
• Web of Science Citations: 3

Abstract

In this study, our goal was to identify the key genes that are associated with obstructive sleep apnea (OSA). Thirty-five volunteers underwent full in-lab polysomnography and, according to the sleep apnea hypopnea index (AHI), were classified into control, mild-to-moderate OSA and severe OSA groups. Severe OSA patients were assigned to participate in a continuous positive airway pressure (CPAP) protocol for 6 months. Blood was collected and the expression of 84 genes analyzed using the RT2 Profiler (TM) PCR array. Mild-to-moderate OSA patients demonstrated down-regulation of 2 genes associated with induction of apoptosis, while a total of 13 genes were identified in severe OSA patients. After controlling for body mass index, PRPF40A and PLOD3 gene expressions were strongly and independently associated with AHI scores. This research protocol highlights a number of molecular targets that might help the development of novel therapeutic strategies. (C) 2013 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 98/14303-3 - Center for Sleep Studies
• Grantee: Sergio Tufik
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC