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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Structural Brain Changes as Biomarkers and Outcome Predictors in Patients with Late-Life Depression: A CrossSectional and Prospective Study

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Author(s):
Ribeiz, Salma R. I. [1] ; Duran, Fabio [2, 3] ; Oliveira, Melaine C. [4] ; Bezerra, Diana [1] ; Castro, Claudio Campi [5] ; Steffens, David C. [6] ; Busatto Filho, Geraldo [2, 3] ; Bottino, Cassio M. C. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Med, Inst Psychiat, Old Age Res Grp Proter, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Psychiat, Lab Psychiat Neuroimaging LIM 21, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Psychiat, Lab Psychiat Neuroimaging LIM 21, Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Math & Stat IME, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Heart Inst InCor, Dept Diagnost Imaging, Sao Paulo - Brazil
[6] Univ Connecticut, Sch Med, Dept Psychiat, Farmington, CT - USA
Total Affiliations: 6
Document type: Journal article
Source: PLoS One; v. 8, n. 11 NOV 14 2013.
Web of Science Citations: 16
Abstract

The relationship between structural changes in grey matter and treatment response in patients with late-life depression remains an intriguing area of research. This magnetic resonance imaging (MRI) study compares the baseline grey matter volume of elderly people with and without major depression (according to the DSM-IV-TR criteria) and assesses its association with antidepressant treatment response. Brain MRI scans were processed using statistical parametric mapping and voxel-based morphometry. The sample consisted of 30 patients with depression and 22 healthy controls. We found a significant volumetric reduction in the orbitofrontal cortex bilaterally in patients in comparison with controls. According to their remission status after antidepressant treatment, patients were classified as remitted or not remitted. Compared with controls, remitted patients showed a volumetric reduction in the orbitofrontal cortex bilaterally and in another cluster in the right middle temporal pole. Non-remitted patients showed an even greater volumetric reduction in the orbitofrontal cortex bilaterally compared with controls. To investigate predictive factors of remission after antidepressant treatment, we used a logistic regression. Both baseline Mini Mental State Examination score and baseline left superior lateral orbitofrontal cortex volume (standardized to the total grey matter volume) were associated with remission status. Our findings support the use of regional brain atrophy as a potential biomarker for depression. In addition, baseline cognitive impairment and regional grey matter abnormalities predict antidepressant response in patients with late-life depression. (AU)