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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

One-pot three-component synthesis of indole-3-glyoxyl derivatives and indole-3-glyoxyl triazoles

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Author(s):
Stefani, Helio A. [1] ; Vasconcelos, Stanley N. S. [1] ; Souza, Frederico B. [1] ; Manarin, Flavia [1] ; Zukerman-Schpector, Julio [2]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo - Brazil
[2] Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Tetrahedron Letters; v. 54, n. 43, p. 5821-5825, OCT 23 2013.
Web of Science Citations: 10
Abstract

A general and efficient reaction of indole with oxalyl chloride and nucleophiles providing indole-3-glyoxyl derivatives has been developed in mild conditions. In the same fashion, the other reaction involved the addition of organic azides leading to the synthesis of indole-3-glyoxyl-1,2,3-triazoles, which proceeds smoothly generating the products in moderate to high yields. (c) 2013 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions
Grantee:Helio Alexandre Stefani
Support Opportunities: Research Projects - Thematic Grants