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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Psychophysically determined full-field stimulus thresholds (FST) in retinitis pigmentosa: relationships with electroretinography and visual field outcomes

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Messias, Katharina [1] ; Jaegle, Herbert [2] ; Saran, Rafael [1] ; Pinto Ruppert, Andre Domingos [1] ; Siqueira, Rubens [1] ; Jorge, Rodrigo [1] ; Messias, Andre [1]
Total Authors: 7
[1] Univ Sao Paulo, Dept Ophthalmol Otorhinolaringol & Head & Neck Su, Med Sch Ribeirao Preto, FMRP, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Regensburg, Dept Ophthalmol, D-93053 Regensburg - Germany
Total Affiliations: 2
Document type: Journal article
Source: DOCUMENTA OPHTHALMOLOGICA; v. 127, n. 2, p. 123-129, OCT 2013.
Web of Science Citations: 9

The purpose of this study is to describe the relationships between full-field stimulus threshold (FST), electroretinography (ERG), and visual field (VF) outcomes in retinitis pigmentosa (RP). Data from 47 patients with RP (n = 94 eyes) were evaluated. Patients were submitted to comprehensive ophthalmological examination including measurement of best-corrected visual acuity (BCVA), 30-2 threshold static VF, and microperimetry. Full-field ERG (ISCEV standard) was recorded, and achromatic FST was measured using a Diagnosys Espion system with the ColorDome (TM) LED full-field stimulator (Diagnosys LLC, Lowell, MA, USA). BCVA mean +/- A SD was 0.31 +/- A 0.03 logMAR, and FST mean +/- A SD was -18.45 +/- A 9.53 dB. No significant correlation was found between BCVA and FST. In contrast, statistically significant correlations were found between FST and static 30-2 VF mean deviation (r = -0.389; P < 0.01), microperimetry mean threshold (r = -0.607; P < 0.01). Dark and light-adapted ERGs were detectable in 28 and 48 eyes, respectively. Nevertheless, considering only the eyes with recordable ERG responses, moderate correlations were found between combined dark-adapted a-wave amplitude (r = -0.560; P < 0.01), b-wave amplitude (r = -0.643; P < 0.001), 30-Hz flicker response (r = -0.501; P < 0.01), and FST, and high correlation with FST for cone b-wave amplitude (r = -0.715; P < 0.01). FST could be successfully determined in RP patients with a wide range of vision loss. FST results showed stronger correlations with full-field ERG amplitude than with sensitivity measured with visual field tests. FST is as an alternative to VF or ERG for assessment of retinal function in patients unable to do visual fields or with non-detectable ERGs. (AU)

FAPESP's process: 10/01714-9 - Fixation pattern in toxoplasmosis chorioretinitis
Grantee:André Marcio Vieira Messias
Support type: Regular Research Grants