Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development and morphology of the inverted yolk sac in the guinea pig (Cavia porcellus)

Full text
Vasconcelos, Bruno Gomes [1] ; Favaron, Phelipe Oliveira [1] ; Miglino, Maria Angelica [1] ; Mess, Andrea Maria [1]
Total Authors: 4
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Surg, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Theriogenology; v. 80, n. 6, p. 636-641, OCT 1 2013.
Web of Science Citations: 6

Although the guinea pig is an important animal model for human placentation, aspects of fetal nutrition are not fully understood, especially in regard to the yolk sac that is regarded to be essential for early development of the embryo. We investigated differentiation by means of histology, histochemistry, immunohistochemistry, and transmission electron microscopy. Data suggest that the guinea pig's yolk sac was not sufficiently developed to facilitate substantial fetal nutrition in early pregnancy. On Day 12, it was a flat, inverted, but avascular structure. This was followed by differentiation to form the typical, highly villous and vascularized condition of advanced gestation. Finally, the yolk sac degenerated toward term. We suggest that the guinea pig and other caviomorphs rely predominantly on hemotrophic nutrition via the placenta even in very early pregnancy. In contrast to the general pattern of mammals, histiotrophic nutrition via yolk sac routes seems to be most essential during mid-gestation. (C) 2013 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/10714-5 - Plan activity browser Andrea Maria Mess november 2011/november 2012
Grantee:Maria Angelica Miglino
Support type: Research Grants - Visiting Researcher Grant - International