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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Orthodontic Force Increases Interleukin-1 beta and Tumor Necrosis Factor-alpha Expression and Alveolar Bone Loss in Periodontitis

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Author(s):
Boas Nogueira, Andressa Vilas [1] ; Chaves de Souza, Joao Antonio [1] ; Kim, Yeon Jung [2] ; de Sousa-Neto, Manoel Damiao [3] ; Cirelli, Carolina Chan ; Cirelli, Joni Augusto [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista UNESP, Sch Dent Araraquara, Dept Diag & Surg, Araraquara - Brazil
[2] Univ Santo Amaro, Dept Implantol, Santo Amaro - Brazil
[3] Univ Sao Paulo, Dept Restorat Dent, BR-14049 Ribeirao Preto - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Periodontology; v. 84, n. 9, p. 1319-1326, SEP 2013.
Web of Science Citations: 17
Abstract

Background: The present study aims to evaluate the effects of orthodontic movement (OM) on the periodontal tissues of rats with ligature-induced periodontal disease. Methods: Eighty-eight rats were divided into four groups: 1) negative control (sham operated); 2) periodontal disease; 3) OM; and 4) periodontal disease followed by OM (OMP). Rats were sacrificed 3 hours or 1, 3, or 7 days after OM commencement. Bone volume fraction (BVF) and bone mineral density (BMD) were assessed in hemimaxillae by microcomputed tomography analysis. Expression of the proinflammatory cytokines interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha were evaluated in gingival samples by quantitative polymerase chain reaction and enzyme-linked immunosorbent assay, and in the furcation region by immunohistochemistry analysis (IHC). Results: The OMP group had lower BVF and BMD levels compared to the other groups at day 7 (P <0.05). Maximum messenger ribonucleic acid expression of both cytokines was observed in the OMP group at day 1 (P <0.05). In the same period, all proteins were expressed in high levels for all test groups compared to the control group. The number of cells positive for IL-1 beta and TNF-alpha by IHC was highest in the OMP group at day 1, with progressive reduction thereafter. Conclusion: The results suggest that OM acts synergistically with periodontal disease in periodontal breakdown through upregulation of proinflammatory cytokines. (AU)

FAPESP's process: 10/07771-4 - Effect of the orthodontic movement in the periodontal disease progression. In vivo and in vitro studies.
Grantee:Andressa Vilas Boas Nogueira
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 08/02506-0 - Effects of orthodontic movement on inflammatory mediators expression in periodontal tissues of rats in health or induced periodontal disease.
Grantee:Andressa Vilas Boas Nogueira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 08/06328-0 - Effects of orthodontic movement on the expression of inflammatory mediators in periodontal tissue of rats with induced periodontal disease or healthy periodontium
Grantee:Joni Augusto Cirelli
Support Opportunities: Regular Research Grants