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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Measurement of Serum and Peritoneal Levels of Amyloid Protein A and Their Importance in the Diagnosis of Pelvic Endometriosis

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Author(s):
Ejzenberg, Dani [1] ; Podgaec, Sergio [1] ; Dias, Jr., Joao Antonio [1] ; de Oliveira, Ricardo Manoel [1] ; Baracat, Edmund Chada [1] ; Abrao, Mauricio Simoes [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept Obstet & Gynecol, Endometriosis Unit, Div Gynecol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF REPRODUCTIVE MEDICINE; v. 58, n. 9-10, p. 411-416, SEP-OCT 2013.
Web of Science Citations: 2
Abstract

OBJECTIVE: To evaluate serum and peritoneal concentrations of amyloid protein A in women with endometriosis and to compare them with those of women without endometriosis. STUDY DESIGN: A prospective study evaluated 76 women suspected of having pelvic endometriosis. Fifty-seven women (group A) were confirmed by videolaparoscopy and had their serum and peritoneal amyloid A concentrations measured by procedure of evaluating the peritoneal amyloid A concentration in endometriosis merits further investigation. ELISA. The average levels from group A were compared to those obtained in group B. Group B was composed of 13 women without endometriosis, submitted to elective laparoscopy for tubal ligation. RESULTS: Peritoneal amyloid A concentrations in group A (310.3 +/- 97.8 ng/mL) were higher than those of group B (53.4 +/- 58.2 ng/mL); p = 0.0. However, serum concentrations in groups A (14.01 +/- 32.3 ng/mL) and B (9.5 +/- 15.9 ng/mL) did not differ significantly; p = 0.35. CONCLUSION: The peritoneal amyloid A protein concentration in pelvic endometriosis was higher when compared to normal controls, corroborating the inflammatory nature of the disease. This finding suggests that the procedure of evaluating the peritoneal amyloid A concentration in endometriosis merits further investigation. (AU)

FAPESP's process: 05/01218-3 - Immunological response evaluation in patients with Endometriosis
Grantee:Maurício Simões Abrão
Support Opportunities: Regular Research Grants