| Full text | |
| Author(s): |
Moura Neto, Arnaldo
[1]
;
Ribeiro Parisi, Maria Candida
[1]
;
Tambascia, Marcos Antonio
[1]
;
Alegre, Sarah Monte
[2]
;
Pavin, Elizabeth Joao
[1]
;
Zantut-Wittmann, Denise Engelbrecht
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Estadual Campinas, Fac Med Sci, Dept Clin Med, Div Endocrinol, BR-13084971 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Dept Clin Med, Div Internal Med, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | ENDOCRINE JOURNAL; v. 60, n. 7, p. 877-884, JUL 2013. |
| Web of Science Citations: | 9 |
| Abstract | |
Previous reports highlight the role of systemic inflammation in the genesis of non-thyroidal illness syndrome and type 2 diabetes mellitus (T2DM). Our objective was to assess whether body mass index and the low-grade systemic inflammation would be associated with changes in thyroid hormone metabolism in patients with type 2 diabetes. This was a cross-sectional study of 104 subjects; 52 patients with type 2 diabetes and 52 in a control group, paired by age, gender and body mass index. We measured total (T) and free (F) thyroxine (T4) and triiodothyronine (T3), reverse T3 (rT3), the ratios FT3/rT3, FT3/FT4 and FT4/rT3, clinical parameters (age, gender, diabetes duration and complications, body mass index, waist circumference, hypertension, HbA1c), and high sensitivity C-reactive protein. Patients with DM presented lower levels of TT4 (p=0.006), TT3 (p<0.001) and FT3 (p<0.001) and higher of FT4 (p<0.001), waist circumference (p=0.047) and C-reactive protein (p<0.001). Body mass index was inversely correlated with FT4 (p=0.036) and TT3 (p=0.008). C-reactive protein was positively correlated with rT3 (p=0.001) and inversely with FT4/rT3 (p<0.001) and FT3/rT3 (p=0.014). Body mass index was an independent predictor for FT4 (B=-0.011, p=0.029) and TT3 levels (B=-1.118, p=0.003). Inflammation predicted the FT4/rT3 ratio (B=-0.190, p<0.001). C-reactive protein (B=0.235, p<0.001) and body mass index (B=-0.008, p=0.047) were independent predictors for rT3. In conclusion, type 2 diabetes was associated with a low T3 state. Body mass index and the low-grade systemic inflammation are related to the non-thyroidal illness syndrome in these patients, possibly by altering the activity of peripheral deiodinases. (AU) | |
| FAPESP's process: | 10/08854-0 - Non-thyroidal illness syndrome in patients with Diabetes mellitus: laboratory pattern and correlation with glycemic control, complications and inflammatory activity |
| Grantee: | Denise Engelbrecht Zantut Wittmann |
| Support type: | Regular Research Grants |